Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
J Infect Dis. 2012 Mar 1;205(5):789-93. doi: 10.1093/infdis/jir851. Epub 2012 Jan 11.
Identifying factors associated with condyloma are necessary for prevention efforts. Risk factors for incident condyloma were examined in a cohort of 2487 men from the United States, Brazil, and Mexico and were followed up every 6 months (median, 17.9 months). Factors strongly associated with condyloma were incident infection with human papillomavirus (HPV) types 6 and 11 (hazard ratio [HR], 12.42 [95% confidence interval {CI}, 3.78-40.77]), age (HR, 0.43 [95% CI, .26-.77]; 45-70 vs 18-30 years), high lifetime number of female partners (HR, 5.69 [95% CI, 1.80-17.97]; ≥21 vs 0 partners), and number of male partners (HR, 4.53 [95% CI, 1.68-12.20]; ≥3 vs 0 partners). The results suggest that HPV types 6 and 11 and recent sexual behavior are strongly associated with incident condyloma.
确定与尖锐湿疣相关的因素对于预防工作至关重要。本研究对来自美国、巴西和墨西哥的 2487 名男性进行了队列研究,每 6 个月随访一次(中位数随访时间为 17.9 个月),以探讨尖锐湿疣的发病风险因素。与尖锐湿疣发病密切相关的因素包括人乳头瘤病毒(HPV)6 型和 11 型的新发感染(风险比 [HR],12.42[95%置信区间 {CI},3.78-40.77])、年龄(HR,0.43[95% CI,0.26-0.77];45-70 岁与 18-30 岁相比)、性伴侣终生数量高(HR,5.69[95% CI,1.80-17.97];≥21 个与 0 个性伴侣相比)和性伴侣数量(HR,4.53[95% CI,1.68-12.20];≥3 个与 0 个性伴侣相比)。研究结果表明,HPV 6 型和 11 型以及近期性行为与尖锐湿疣的发病密切相关。