天花疫苗接种停止后人类猴痘的爆发。

Outbreaks of human monkeypox after cessation of smallpox vaccination.

机构信息

Division of High-consequence Pathogens and Pathology, US Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G-43, Atlanta, GA 30333, USA.

出版信息

Trends Microbiol. 2012 Feb;20(2):80-7. doi: 10.1016/j.tim.2011.12.001. Epub 2012 Jan 10.

DOI:10.1016/j.tim.2011.12.001

PMID:22239910

Abstract

The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the virus's mechanisms for immune evasion and induction, as well as that directed at elucidating the genes involved in pathogenesis in different viral lineages (West African vs Congo Basin), provide insights to help explain why emergence appears to be geographically limited. Novel vaccines offer one solution to curtail the spread of this disease.

摘要

最近在刚果民主共和国（DRC）观察到人类猴痘病例激增，这引发了一个问题，即天花疫苗的停止接种是否是导致这一现象的原因，如果是，为什么病毒在其历史地理范围内没有普遍重新出现？研究旨在阐明病毒的免疫逃逸和诱导机制，以及阐明不同病毒谱系（西非与刚果盆地）中发病机制相关基因的研究，提供了一些见解，有助于解释为什么这种疾病的出现似乎具有地理局限性。新型疫苗是遏制这种疾病传播的一种解决方案。