Universidade Federal do Pará, Belém, PA, Brazil.
Mem Inst Oswaldo Cruz. 2011 Dec;106(8):936-41. doi: 10.1590/s0074-02762011000800007.
The histo-blood group ABH antigens were first described in humans. These antigens are only present on erythrocytes from great apes and humans, while in more primitive animals they are found in tissues and body fluids. The ABH antigens are mainly distributed in tissues exposed to the external environment and potentially serve as ligands for pathogens or inhibitors of tissue connections. The objective of this paper was two-fold: (i) to determine the presence of Helicobacter sp. in the gastric mucosa of 16 captive and 24 free-living New World monkeys and (ii) to evaluate the presence of histopathological alterations related to bacterial infection and the associated expression of ABH antigens in the tissue. Stomach tissues from 13 species of monkey were assessed using haematoxylin-eosin and modified Gram staining (Hucker) methods. An immunohistochemical analysis of the tissue revealed the presence of infectious bacteria that were characteristic of the genus Helicobacter sp. The results demonstrate that various species of monkey might be naturally infected with the Helicobacter sp. and that there is an increased susceptibility to infection. This study serves as a comparative analysis of infection between human and non-human primates and indicates the presence of a new species of Helicobacter.
人类首次描述了组织血型 ABH 抗原。这些抗原仅存在于大猿类和人类的红细胞上，而在更原始的动物中，它们存在于组织和体液中。ABH 抗原主要分布在暴露于外部环境的组织中，可能作为病原体的配体或组织连接的抑制剂。本文的目的有两个：（i）确定 16 只圈养和 24 只自由生活的新世界猴胃黏膜中是否存在幽门螺旋杆菌；（ii）评估与细菌感染相关的组织病理学改变以及组织中 ABH 抗原的表达。使用苏木精-伊红和改良革兰氏染色（Hucker）方法评估了 13 种猴的胃组织。组织的免疫组织化学分析显示存在特征性的幽门螺旋杆菌属感染性细菌。结果表明，不同种类的猴子可能自然感染了幽门螺旋杆菌，并且感染的易感性增加。本研究对人类和非人类灵长类动物之间的感染进行了比较分析，并表明存在一种新的幽门螺旋杆菌物种。
