Caldis-Coutris Nancy, Gawaziuk Justin P, Logsetty Sarvesh
Firefighters' Burn Unit, Health Sciences Centre, Winnipeg, Manitoba, Canada.
J Burn Care Res. 2012 Sep-Oct;33(5):678-82. doi: 10.1097/BCR.0b013e31824799a3.
Micronutrient supplementation is a common practice throughout many burn centers across North America; however, uncertainty pertaining to dose, duration, and side effects of such supplements persists. The authors prospectively collected data from 23 hospitalized patients with burn sizes ranging from 10 to 93% TBSA. Each patient received a daily multivitamin and mineral supplement, 50 mg zinc (Zn) daily, and 500 mg vitamin C twice daily. Supplements were administered orally or enterally. Albumin, prealbumin, C-reactive protein, serum Zn, and serum copper were measured weekly during hospital admission until levels were within normal reference range. Our study concluded that 50 mg daily dose of Zn resulted in normal serum levels in 19 of 23 patients at discharge; 50 mg Zn supplementation did not interfere with serum copper levels; and Zn supplements, regardless of administration route, did not result in gastrointestinal side effects.
在北美众多烧伤中心,微量营养素补充是一种常见做法;然而,此类补充剂的剂量、持续时间和副作用仍存在不确定性。作者前瞻性地收集了23例住院烧伤患者的数据,烧伤面积从10%到93%TBSA不等。每位患者每天接受多种维生素和矿物质补充剂、每日50毫克锌(Zn)以及每日两次500毫克维生素C。补充剂通过口服或肠内途径给药。在住院期间每周测量白蛋白、前白蛋白、C反应蛋白、血清锌和血清铜,直至水平在正常参考范围内。我们的研究得出结论,23例患者中有19例在出院时每日50毫克的锌剂量使血清水平正常;补充50毫克锌不影响血清铜水平;且锌补充剂无论给药途径如何,均未导致胃肠道副作用。