鉴定绛红小单孢菌 ATCC49982 中赫氏菌素生物合成基因簇。
Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.
机构信息
Department of Biological Engineering, Utah State University, Logan, Utah, USA.
出版信息
Appl Environ Microbiol. 2012 Mar;78(6):2034-8. doi: 10.1128/AEM.06904-11. Epub 2012 Jan 13.
Abstract
The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.
摘要
通过基因组测序和基因失活，从链霉菌属 chromofuscus ATCC 49982 中鉴定出了新型抗胆固醇天然产物 herboxidiene 的 53kb 生物合成基因簇。除了 herboxidiene 这种生物合成中间体外，还从链霉菌属 chromofuscus ATCC 49982 的发酵液中分离出了 18-脱氧-herboxidiene 作为次要代谢产物。
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