Bryne M, Thrane P S, Dabelsteen E
Department of Oral Pathology, University of Oslo, Norway.
Cancer. 1990 Nov 15;66(10):2118-23. doi: 10.1002/1097-0142(19901115)66:10<2118::aid-cncr2820661013>3.0.co;2-2.
Membrane-bound carbohydrates may influence the metastatic behavior of cancer cells. Forty-two squamous cell carcinomas (SCC) of the buccal and maxillary alveolar mucosa were studied retrospectively using a monoclonal antibody (BE2) that reacts with blood group H (type 2 chain) structure and an immunoperoxidase (avidin-biotin peroxidase complex) staining technique. H-antigen staining within the entire tumor did not correlate with the stage of the tumor, i.e., tumor spread. However, loss of staining within the most invasive sites of the tumors correlated significantly with the stage of tumor development and histologic grade of malignancy. These findings support the view that features regarding the cells of deeper parts of the carcinomas are very important for the clinical behavior of the tumors and that loss of H-antigen expression is related to the stage of the tumor and invasion of carcinoma cells.
膜结合碳水化合物可能影响癌细胞的转移行为。使用与血型H（2型链）结构反应的单克隆抗体（BE2）和免疫过氧化物酶（抗生物素蛋白-生物素过氧化物酶复合物）染色技术，对42例颊部和上颌牙槽黏膜鳞状细胞癌（SCC）进行了回顾性研究。整个肿瘤内的H抗原染色与肿瘤分期即肿瘤扩散无关。然而，肿瘤最具侵袭性部位的染色缺失与肿瘤发展阶段和恶性组织学分级显著相关。这些发现支持了这样一种观点，即关于癌深部细胞的特征对肿瘤的临床行为非常重要，并且H抗原表达的缺失与肿瘤分期和癌细胞侵袭有关。
