Panda S K, Dutta S K, Bastia A K
Department of Biotechnology, North Orissa University, Baripada, Orissa, India.
J Adv Pharm Technol Res. 2010 Oct;1(4):419-22. doi: 10.4103/0110-5558.76442.
In this study, the antibacterial activity of crude (aqueous and alcoholic) extracts of the bark and leaf of Croton roxburghii Balak. (Euphorbiaceae) was tested against enteric pathogens causing urinary tract infection (UTI) using the agar cup method, minimum inhibitory concentration (MIC), time kill kinetics and synergy study. The ethanol extract exhibited a significant and broad spectrum of inhibition as compared to the aqueous extract of both the bark and leaf. The highest antibacterial activity was observed against Staphylococcus aureus followed by enteropathogenic and enterotoxigenic Escherichia coli. The diameter of inhibition zones varied from 10 to 18 mm for both aqueous and alcoholic extracts. The MIC value ranged from 356 to 625 μg/ml. This could justify the traditional use of this plant in dysentery and other infections.
在本研究中，采用琼脂杯法、最低抑菌浓度（MIC）、时间杀菌动力学和协同研究，测试了巴豆（大戟科）树皮和树叶的粗提物（水提取物和醇提取物）对引起尿路感染（UTI）的肠道病原体的抗菌活性。与树皮和树叶的水提取物相比，乙醇提取物表现出显著且广谱的抑制作用。观察到对金黄色葡萄球菌的抗菌活性最高，其次是肠致病性和产肠毒素的大肠杆菌。水提取物和醇提取物的抑菌圈直径在10至18毫米之间。MIC值范围为356至625微克/毫升。这可以证明该植物在治疗痢疾和其他感染方面的传统用途是合理的。
