Department of Neurology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
Int J Neurosci. 2012 Jul;122(7):367-72. doi: 10.3109/00207454.2012.657380. Epub 2012 Feb 20.
To date, there have not been enough studies about the effects of curcumin against oxidative stress on sciatic nerves caused by streptozotocin (STZ) in diabetic rats. Therefore, this study was undertaken to determine whether curcumin, by virtue of its antioxidant properties, could affect the oxidant/antioxidant balance in the sciatic nerve and brain tissues of streptozotocin (STZ)-induced diabetic rats. A total of 28 rats were randomly divided into four groups of seven rats each: normal controls, only curcumin treated, diabetic controls, and diabetics treated with curcumin. Biomarkers-malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and NO levels-for oxidative stress in the brain and sciatic nerve tissues of the rats were measured. We found a significant increase in MDA, NO, TOS, and OSI, along with a reduction in TAS levels in the brains and sciatic nerves of the STZ-induced diabetic rats (for both parameters p < 0.05). The MDA, TOS, OSI, and NO levels in these tissues were significantly reduced in the curcumin-treated diabetic group compared to the untreated diabetic group. In conclusion, the results of this study suggested that curcumin exhibits neuroprotective effects against oxidative damage in the brain and sciatic tissues of diabetic rats.
迄今为止，关于姜黄素对链脲佐菌素（STZ）诱导的糖尿病大鼠坐骨神经氧化应激的影响的研究还不够充分。因此，本研究旨在确定姜黄素是否因其抗氧化特性而影响糖尿病大鼠坐骨神经和脑组织中的氧化应激/抗氧化平衡。总共 28 只大鼠被随机分为四组，每组 7 只：正常对照组、仅用姜黄素处理组、糖尿病对照组和糖尿病用姜黄素处理组。测量了大鼠脑和坐骨神经组织中的生物标志物-丙二醛（MDA）、总氧化剂状态（TOS）、总抗氧化状态（TAS）、氧化应激指数（OSI）和 NO 水平，以评估氧化应激。我们发现，STZ 诱导的糖尿病大鼠的大脑和坐骨神经中的 MDA、NO、TOS 和 OSI 显著增加，而 TAS 水平降低（两种参数均 p<0.05）。与未治疗的糖尿病组相比，用姜黄素治疗的糖尿病组这些组织中的 MDA、TOS、OSI 和 NO 水平显著降低。总之，本研究的结果表明，姜黄素对糖尿病大鼠的大脑和坐骨神经组织的氧化损伤具有神经保护作用。
