Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
Soc Psychiatry Psychiatr Epidemiol. 2012 Oct;47(10):1649-56. doi: 10.1007/s00127-011-0471-8. Epub 2012 Jan 15.
Khat use has been suggested to be associated with psychosis, but its prevalence and associations among mental health service users have not been described in either traditional use countries or countries with immigrant populations from traditional use countries. We aimed to investigate the clinical and demographic associations of khat use in a sample of Somali users of mental health service users in South London.
We used an electronic case register of 150,000 mental health patients to investigate the associations of khat use among all 240 Somali patients in the database. We used logistic regression to generate adjusted estimates for a range of exposure variables and used multiple imputation as a principled approach to missing data.
Khat use or non-use was recorded for 172 patients (72% of the total), of whom 80 (47%) were current users. Khat use was very strongly associated with ICD-10 primary diagnosis of schizophrenia, psychosis or drug and alcohol disorder (compared to ICD-10 F43 stress-related disorders and other non-psychotic disorders), male gender, harmful or dependent use of alcohol, and detention under the Mental Health Act.
Recording and monitoring of khat use need to be more consistent in clinical settings, and further studies are required to investigate the much higher rates of use among those with psychotic disorders compared to non-psychotic disorders.
有研究表明，阿拉伯茶的使用与精神病有关，但在传统使用国家或有来自传统使用国家移民人口的国家，尚未对精神卫生服务使用者中阿拉伯茶的使用频率及其相关情况进行描述。我们旨在调查伦敦南部的一个索马里精神卫生服务使用者样本中阿拉伯茶使用与临床和人口统计学因素的关联。
我们使用了一个包含 15 万名精神健康患者的电子病例登记系统，来调查数据库中所有 240 名索马里患者中阿拉伯茶使用的关联情况。我们使用逻辑回归生成了一系列暴露变量的调整估计值，并使用多重插补作为处理缺失数据的原则性方法。
记录了 172 名患者（占总数的 72%）使用或未使用阿拉伯茶，其中 80 名（47%）为当前使用者。阿拉伯茶的使用与 ICD-10 精神分裂症、精神病或药物和酒精障碍的主要诊断（与 ICD-10 F43 应激相关障碍和其他非精神病障碍相比）、男性性别、酒精的有害或依赖使用以及根据《精神卫生法》拘留有很强的关联。
在临床环境中，需要更一致地记录和监测阿拉伯茶的使用情况，还需要进一步研究为什么在有精神病障碍的患者中阿拉伯茶的使用率比非精神病障碍患者高得多。
