Kantorová E
Oddĕlení lékarské genetiky KUNZ, Ceské Budĕjovice.
Cas Lek Cesk. 1990 Sep 28;129(39):1228-31.
In a group of 70 probands treated on account of ischaemic heart disease manifested before the age of 55 years and in the grade I and II offspring the presence of other risk factors of the disease was assessed--smoking, arterial hypertension, obesity and diabetes mellitus. This part II is a continuation of the previous paper where the ratio of hyperlipoproteinaemias in the group was assessed. The probands comprised 62.9% smokers, 25.7% hypertonic subjects, 68.6% obese subjects and 20% diabetics. Risk factors were found only in grade I offspring--29.4% smokers, 2.4% hypertonic subjects and 16.7% obese subjects. The author emphasizes the fact that almost 40% of the offspring under 35 years of age with a family-history of early ischaemic heart disease have at least one risk factor of the disease.
在一组70名因55岁之前出现的缺血性心脏病接受治疗的先证者及其Ⅰ级和Ⅱ级后代中,评估了该疾病的其他危险因素——吸烟、动脉高血压、肥胖和糖尿病。本第二部分是前文的延续,前文评估了该组中高脂蛋白血症的比例。先证者中吸烟者占62.9%,高血压患者占25.7%,肥胖者占68.6%,糖尿病患者占20%。仅在Ⅰ级后代中发现了危险因素——吸烟者占29.4%,高血压患者占2.4%,肥胖者占16.7%。作者强调了这样一个事实,即有早发性缺血性心脏病家族史的35岁以下后代中,近40%至少有该疾病的一种危险因素。