Luzzati A L, Heinzer I, Hengartner H, Schreier M H
Clin Exp Immunol. 1979 Mar;35(3):405-12.
Normal human peripheral blood lymphocytes, stimulated in vitro with SRBC in the presence of Epstein-Barr virus (EBV), gave rise to plaque-forming cells (PFC) specific for the antigen. PFC levels were very low before day 4 and increased thereafter, reaching a maximum around day 8. However, the kinetics of the response varied considerably from donor to donor and from experiment to experiment. In some instances a second peak of PFC was obtained beyond day 10. Large differences in the magnitude of the response were observed among different normal donors, the overall responsiveness range covering four orders of magnitude. Peripheral blood lymphocytes from infectious mononucleosis patients in the acute stage of the disease, when a high titre of heterophil and anti-EBV antibodies were present, did not give rise to PFC. A return to normal responses was observed during recovery from the disease.
在体外，正常人类外周血淋巴细胞在存在爱泼斯坦 - 巴尔病毒（EBV）的情况下用绵羊红细胞（SRBC）刺激后，产生了针对该抗原的噬斑形成细胞（PFC）。在第4天之前PFC水平非常低，此后升高，在第8天左右达到最大值。然而，不同供体之间以及不同实验之间反应的动力学有很大差异。在某些情况下，在第10天之后获得了PFC的第二个峰值。在不同的正常供体中观察到反应强度的巨大差异，总体反应性范围涵盖四个数量级。处于疾病急性期的传染性单核细胞增多症患者的外周血淋巴细胞，当存在高滴度的嗜异性抗体和抗EBV抗体时，不会产生PFC。在疾病恢复过程中观察到反应恢复正常。
