ω-3 指数与心源性猝死。
Omega-3 Index and sudden cardiac death.
机构信息
Preventive Cardiology, Medizinische Klinik and Poliklinik Innenstadt, Ludwig Maximilians University Munich, Ziemssenstr. 1, 80336 Munich, Germany.
Omegametrix, Am Klopferspitz 19, 82152 Martinsried, Germany.
出版信息
Nutrients. 2010 Mar;2(3):375-388. doi: 10.3390/nu2030375. Epub 2010 Mar 23.
Abstract
Sudden cardiac death (SCD) is an unresolved health issue, and responsible for 15% of all deaths in Western countries. Epidemiologic evidence, as well as evidence from clinical trials, indicates that increasing intake and high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect from SCD and other major adverse cardiac events. Levels of EPA+DHA are best assessed by the Omega-3 Index, representing the red cell fatty acid content of EPA+DHA. Work is in progress that will further define the value of the Omega-3 Index as a risk factor for SCD, other cardiac events, and as target for treatment with EPA+DHA.
摘要
心脏性猝死（SCD）是一个尚未解决的健康问题，占西方国家所有死亡人数的 15%。流行病学证据以及临床试验证据表明，增加二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的摄入量并保持高水平，可以预防 SCD 和其他主要不良心脏事件。EPA+DHA 的水平最好通过 ω-3 指数来评估，代表红细胞中 EPA+DHA 的脂肪酸含量。目前正在进行进一步研究，以确定 ω-3 指数作为 SCD、其他心脏事件的风险因素以及 EPA+DHA 治疗目标的价值。
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