Tuan Hoang-Trong Minh, Williams George S B, Chikando Aristide C, Sobie Eric A, Lederer W Jonathan, Jafri M Saleet
School of Systems Biology, George Mason University, Manassas, VA 20110,
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:4677-80. doi: 10.1109/IEMBS.2011.6091158.
A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
建立了大鼠心室肌细胞钙动力学的三维模型，以研究钙稳态机制以及钙超载期间的病理性钙动力学。该模型包含20,000个钙释放单元（CRU），每个单元含有49个兰尼碱受体。该模型以实际的自发钙火花率模拟钙火花。结果表明，除了基于钙火花的泄漏外，每个CRU中少量兰尼碱受体的随机开放会导致不可见的钙泄漏，而不会触发钙火花。该模型还探讨了钙超载条件下释放位点之间钙波传播的机制。
