心室肌细胞钙动力学和钙波的随机模拟
Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.
作者信息
Tuan Hoang-Trong Minh, Williams George S B, Chikando Aristide C, Sobie Eric A, Lederer W Jonathan, Jafri M Saleet
机构信息
School of Systems Biology, George Mason University, Manassas, VA 20110,
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:4677-80. doi: 10.1109/IEMBS.2011.6091158.
Abstract
A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.
摘要
建立了大鼠心室肌细胞钙动力学的三维模型，以研究钙稳态机制以及钙超载期间的病理性钙动力学。该模型包含20,000个钙释放单元（CRU），每个单元含有49个兰尼碱受体。该模型以实际的自发钙火花率模拟钙火花。结果表明，除了基于钙火花的泄漏外，每个CRU中少量兰尼碱受体的随机开放会导致不可见的钙泄漏，而不会触发钙火花。该模型还探讨了钙超载条件下释放位点之间钙波传播的机制。
相似文献
1
Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.心室肌细胞钙动力学和钙波的随机模拟
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:4677-80. doi: 10.1109/IEMBS.2011.6091158.
2
Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling.雷诺丁受体敏感性决定心脏兴奋-收缩偶联过程中局部钙释放的稳定性和同步性。
J Mol Cell Cardiol. 2016 Mar;92:82-92. doi: 10.1016/j.yjmcc.2016.01.024. Epub 2016 Jan 28.
3
Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves.增加 SERCA 功能可促进钙火花的起始和钙波的破裂。
J Physiol. 2021 Jul;599(13):3267-3278. doi: 10.1113/JP281579. Epub 2021 Jun 5.
4
Evolution of cardiac calcium waves from stochastic calcium sparks.心脏钙波从随机钙火花的演变。
Biophys J. 2001 Jan;80(1):103-20. doi: 10.1016/S0006-3495(01)75998-X.
5
Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes.心室肌细胞自发性细胞内 Ca2+波的起始和发展的计算建模。
Philos Trans A Math Phys Eng Sci. 2010 Aug 28;368(1925):3953-65. doi: 10.1098/rsta.2010.0146.
6
Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.大小有别：兰尼碱受体簇大小异质性增强钙离子波。
Biophys J. 2019 Feb 5;116(3):530-539. doi: 10.1016/j.bpj.2018.12.017. Epub 2019 Jan 3.
7
Eavesdropping on the social lives of Ca(2+) sparks.窃听钙离子火花的社交生活
Biophys J. 2007 Nov 15;93(10):3408-20. doi: 10.1529/biophysj.107.112466. Epub 2007 Aug 3.
8
A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation.大鼠心室肌细胞钙动力学的随机时空模型展示了钙波传播的必要特征。
Membranes (Basel). 2021 Dec 18;11(12):989. doi: 10.3390/membranes11120989.
9
Spontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes.在渗透的心室肌细胞的最小模型中，自发的 Ca2+火花和 Ca2+动态平衡。
Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1996-2008. doi: 10.1152/ajpheart.00293.2010. Epub 2010 Sep 17.
10
Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes.β-肾上腺素能刺激使心肌细胞中Ca2+释放不应期达到最大加速，需要蛋白激酶A（PKA）和钙/钙调蛋白依赖性蛋白激酶II（CaMKII）的双重激活。
J Physiol. 2015 Mar 15;593(6):1495-507. doi: 10.1113/jphysiol.2014.278051. Epub 2014 Oct 7.
引用本文的文献
1
Calcium Sparks in the Heart: Dynamics and Regulation.心脏中的钙火花：动力学与调节
Res Rep Biol. 2015;6:203-214. doi: 10.2147/RRB.S61495. Epub 2015 Oct 16.
2
Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.计算心脏病学与心脏性猝死的风险分层：21世纪心脏病学面临的重大挑战之一。
J Physiol. 2016 Dec 1;594(23):6893-6908. doi: 10.1113/JP272015. Epub 2016 Jun 9.
3
Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.肌质网钙释放通道的层次聚类使窦房结细胞中出现钙离子时钟。
J Gen Physiol. 2014 May;143(5):577-604. doi: 10.1085/jgp.201311123.
本文引用的文献
1
A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation.大鼠心室肌细胞钙动力学的随机时空模型展示了钙波传播的必要特征。
Membranes (Basel). 2021 Dec 18;11(12):989. doi: 10.3390/membranes11120989.
2
Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes.正常和衰竭的兔心室肌细胞中 Ca²+ 火花依赖和非依赖的肌浆网 Ca²+ 渗漏。
J Physiol. 2010 Dec 1;588(Pt 23):4743-57. doi: 10.1113/jphysiol.2010.197913. Epub 2010 Oct 20.
3
Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.钙火花并不能解释小鼠心室肌细胞中所有ryanodine 受体介导的 SR Ca 泄漏。
Biophys J. 2010 May 19;98(10):2111-20. doi: 10.1016/j.bpj.2010.01.042.
4
A thermodynamic model of the cardiac sarcoplasmic/endoplasmic Ca(2+) (SERCA) pump.心脏肌浆网/内质网Ca(2+)（SERCA）泵的热力学模型。
Biophys J. 2009 Mar 4;96(5):2029-42. doi: 10.1016/j.bpj.2008.11.045.
5
Ryanodine receptor allosteric coupling and the dynamics of calcium sparks.兰尼碱受体变构偶联与钙火花动力学
Biophys J. 2008 Jul;95(1):135-54. doi: 10.1529/biophysj.107.119982. Epub 2008 Mar 21.
6
Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants.单个心肌兰尼碱受体的管腔Ca2+调节：肌集钙蛋白及其突变体提供的见解
J Gen Physiol. 2008 Apr;131(4):325-34. doi: 10.1085/jgp.200709907. Epub 2008 Mar 17.
7
Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes.心肌细胞中兰尼碱受体簇的三维分布
Biophys J. 2006 Jul 1;91(1):1-13. doi: 10.1529/biophysj.105.077180. Epub 2006 Apr 7.
8
The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice.钙离子泄漏悖论与异常的兰尼碱受体：肌浆网钙离子外流的理论与实践
Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):172-85. doi: 10.1016/j.pbiomolbio.2005.06.010. Epub 2005 Jul 18.
9
A stochastic automata network descriptor for Markov chain models of instantaneously coupled intracellular Ca2+ channels.用于瞬时耦合细胞内Ca2+通道马尔可夫链模型的随机自动机网络描述符。
Bull Math Biol. 2005 May;67(3):393-432. doi: 10.1016/j.bulm.2004.08.010.
10
Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles.骨骼肌和心肌中钙（Ca²⁺）释放单元和偶联子的形状、大小及分布。
Biophys J. 1999 Sep;77(3):1528-39. doi: 10.1016/S0006-3495(99)77000-1.
Zotero 插件