School of Health Sciences, University of Tampere, Tampere, Finland.
Health Qual Life Outcomes. 2012 Jan 23;10:8. doi: 10.1186/1477-7525-10-8.
The aim of this study was to study the role of menopausal status and physical activity on quality of life.
A total of 1,165 Finnish women aged 45-64 years from a national representative population-based study were followed up for 8 years. Study participants completed the Health 2000 study questionnaire and follow-up questionnaire in 2008. Ordinal logistic regression analysis was used to measure the effect of menopausal status on global quality of life (QoL). Other variables included in the analyses were age, education, change of physical activity as assessed with metabolic equivalents, change of weight and hormone therapy (HRT) use.
Peri- and postmenopausal women increased their physical activity (28% and 27%) during the eight-year follow up period slightly more often than premenopausal (18%) women (p = 0.070). Menopausal status was not significantly correlated with change of QoL. QoL of the most highly educated women was more likely to improve than among the less educated (eb = 1.28, 95%CI 1.08 to 1.51 p = 0.002). Women whose physical activity increased or remained stable had greater chances for improved QoL than women whose physical activity decreased (eb = 1.49, 95%CI 1.23 p < 0.001 to 1.80, eb = 1.46, 95%CI 1.24 to 1.73 p < 0.001 respectively). Women whose weight remained stable during follow-up also improved their QoL compared to women who gained weight (eb = 1.26, 95%CI 1.07 to 1.50 p > 0.01). Women who had never used HRT had 1.26 greater odds for improved QoL (95%CI 1.02 to 1.56 p = < 0.05).
Improvement of global QoL is correlated with stable or increased physical activity, stable weight and high education, but not with change in menopausal status.
本研究旨在探讨绝经状态和身体活动对生活质量的影响。
本研究共纳入了来自全国代表性人群的 1165 名年龄在 45-64 岁的芬兰女性，对其进行了 8 年的随访。研究参与者在 2008 年完成了健康 2000 研究问卷和随访问卷。采用有序逻辑回归分析来评估绝经状态对整体生活质量（QoL）的影响。纳入分析的其他变量包括年龄、教育程度、通过代谢当量评估的身体活动变化、体重变化和激素治疗（HRT）使用情况。
在 8 年的随访期间，围绝经期和绝经后女性（分别为 28%和 27%）的身体活动量略有增加，而绝经前女性（18%）则略有减少（p=0.070）。绝经状态与 QoL 的变化无显著相关性。受教育程度较高的女性的 QoL 更有可能改善，而受教育程度较低的女性则不太可能改善（eb=1.28，95%CI 1.08-1.51，p=0.002）。与身体活动量减少的女性相比，身体活动量增加或保持稳定的女性有更大的机会改善 QoL（eb=1.49，95%CI 1.23-1.80，eb=1.46，95%CI 1.24-1.73，均 p<0.001）。与体重增加的女性相比，随访期间体重保持稳定的女性的 QoL 也有所改善（eb=1.26，95%CI 1.07-1.50，p>0.01）。从未使用过 HRT 的女性改善 QoL 的可能性增加了 1.26 倍（95%CI 1.02-1.56，p=0.05）。
整体 QoL 的改善与稳定或增加的身体活动量、稳定的体重和较高的教育程度相关，而与绝经状态的变化无关。
