Ministry of Health Key Laboratory of Congenital Malformation, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China.
Molecules. 2012 Jan 16;17(1):836-42. doi: 10.3390/molecules17010836.
Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 mM.
从链霉菌属 sannanensis 的发酵液中分离得到了两个新化合物，异链霉素（1）和山萘酚（2），并通过 1D 和 2D NMR 以及 MS、IR 和 UV 光谱数据分析确定了它们的结构。评估了 1 和 2 的细胞毒性活性。在 100mM 时，这两种化合物对 H460 和 HeLa 细胞系均无活性。
