Song Daesub, Park Bongkyun
Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, South Korea.
Virus Genes. 2012 Apr;44(2):167-75. doi: 10.1007/s11262-012-0713-1. Epub 2012 Jan 22.
The porcine epidemic diarrhoea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhoea and dehydration in pigs. Although it was first identified in Europe, it has become increasingly problematic in many Asian countries, including Korea, China, Japan, the Philippines, and Thailand. The economic impacts of the PEDV are substantial, given that it results in significant morbidity and mortality in neonatal piglets and is associated with increased costs related to vaccination and disinfection. Recently, progress has been made in understanding the molecular epidemiology of PEDV, thereby leading to the development of new vaccines. In the current review, we first describe the molecular and genetic characteristics of the PEDV. Then we discuss its molecular epidemiology and diagnosis, what vaccines are available, and how PEDV can be treated.
猪流行性腹泻病毒（PEDV）是冠状病毒科的成员之一，可导致猪出现急性腹泻和脱水症状。尽管它最初是在欧洲被发现的，但在包括韩国、中国、日本、菲律宾和泰国在内的许多亚洲国家，它引发的问题日益严重。鉴于PEDV会导致新生仔猪出现显著的发病率和死亡率，并与疫苗接种和消毒相关成本增加有关，其经济影响颇为巨大。最近，在了解PEDV的分子流行病学方面取得了进展，从而推动了新型疫苗的研发。在本综述中，我们首先描述PEDV的分子和遗传特征。然后我们讨论其分子流行病学、诊断方法、现有哪些疫苗以及PEDV如何进行治疗。
