Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
Int J Obes (Lond). 2012 Dec;36(12):1545-51. doi: 10.1038/ijo.2011.278. Epub 2012 Jan 24.
Circulating angiotensin-converting enzyme (ACE) was identified as a predictor of weight loss maintenance in overweight/obese women of the Diogenes project.
To investigate whether ACE acted also as a predictor in men of the Diogenes study and to compare it with that in women.
Subjects, who lost ≥ 8% of body weight induced by low-caloric diet in an 8-week weight loss period, were assigned to weight loss maintenance with dietary intervention for 6 months.
125 overweight/obese healthy men from eight European countries who completed whole intervention.
Concentrations and activity of serum ACE at baseline and after the 8-week weight loss, in addition to anthropometric and physiological parameters.
Serum ACE concentration decreased by 11.3 ± 10.6% during the weight loss period in men. A greater reduction is associated with less body weight regain during the maintenance period (r=0.227, P=0.012). ACE change was able to predict a weight regain ≤ 20% after 6 months, with an odds ratio of 1.59 (95% confidence interval (CI): 1.09-2.33, P=0.016) for every 10% reduction, which was independent of body mass index and weight loss. The prediction power was weaker in men than in women, but without a significant sex difference (P=0.137). In pooled subjects (N=218), the odds ratio was 1.96 (95% CI: 1.46-2.64, P<0.001).
A greater reduction of ACE during weight loss is favorable for weight maintenance in both men and women. This can offer useful information for personalized advice to improve weight loss maintenance. It also confirms the role of ACE in the metabolic pathways of weight regulation.
循环血管紧张素转换酶（ACE）被鉴定为超重/肥胖的 Diogenes 项目女性体重维持的预测因子。
研究 ACE 是否也可以作为 Diogenes 研究男性的预测因子，并与女性进行比较。
在 8 周的减肥期内通过低热量饮食诱导体重减轻≥8%的受试者被分配进行 6 个月的饮食干预以维持体重。
来自八个欧洲国家的 125 名超重/肥胖健康男性完成了整个干预。
在基线和 8 周减肥后测量血清 ACE 的浓度和活性，以及人体测量学和生理学参数。
男性在减肥期间血清 ACE 浓度降低了 11.3±10.6%。在维持期间体重恢复较少与 ACE 减少量较大相关（r=0.227，P=0.012）。ACE 变化能够预测 6 个月后体重恢复≤20%，每减少 10%，其比值比为 1.59（95%置信区间（CI）：1.09-2.33，P=0.016），这与体重指数和体重减轻无关。这种预测能力在男性中比在女性中较弱，但无显著性别差异（P=0.137）。在合并的受试者（N=218）中，比值比为 1.96（95%CI：1.46-2.64，P<0.001）。
在减肥期间 ACE 减少较多有利于男女的体重维持。这为改善体重维持提供了有用的信息。它还证实了 ACE 在体重调节代谢途径中的作用。
