Vink Roel G, Roumans Nadia J, Mariman Edwin C, van Baak Marleen A
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, the Netherlands.
Physiol Rep. 2017 Nov;5(21). doi: 10.14814/phy2.13450.
Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled trial 26 males and 30 females (BMI: 28-35 kg/m) followed either a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks followed by a weight stable period of 4 weeks (dietary intervention (DI) period) and a 9-month follow-up period. Blood samples were taken before and after each period to measure FFA, TAG, total cholesterol, insulin, glucose, angiotensin-converting enzyme (ACE) activity, IL-6, RBP4, apelin, leptin, adiponectin, vaspin, and nesfatin-1 concentrations. Weight loss was similar between groups (LCD: -8.2 ± 0.5 kg; VLCD: -8.9 ± 0.4 kg, =0.30). Only changes in ACE activity, FFA and RBP4 concentrations during DI were correlated with weight regain in the whole group ( = -0.299, =0.030, = -0.274, 0.047, and = 0.357, =0.008, respectively). Together they explained 28% ( = 0.532) of weight regain variation. Dietary weight loss-induced changes in ACE activity, FFA and RBP4 independently contribute to weight regain prediction.
脂肪因子和其他生物标志物先前已被确定在能量消耗、食欲、饱腹感和肥胖症中发挥作用。因此，我们研究了饮食减肥引起的脂肪因子和其他已知在体重调节或能量消耗中起作用的生物标志物的变化是否能预测超重和肥胖人群的体重反弹。在这项随机对照试验中，26名男性和30名女性（BMI：28 - 35 kg/m²）要么遵循低热量饮食（LCD；1250千卡/天）12周，要么遵循极低热量饮食（VLCD；500千卡/天）5周，随后是4周的体重稳定期（饮食干预（DI）期）和9个月的随访期。在每个时期前后采集血样，以测量游离脂肪酸（FFA）、甘油三酯（TAG）、总胆固醇、胰岛素、葡萄糖、血管紧张素转换酶（ACE）活性、白细胞介素 - 6（IL - 6）、视黄醇结合蛋白4（RBP4）、脂联素、内脂素、内脏脂肪素和神经肽Y（nesfatin - 1）的浓度。两组之间的体重减轻相似（LCD：-8.2±0.5千克；VLCD：-8.9±0.4千克，P = 0.30）。在整个组中，只有DI期间ACE活性、FFA和RBP4浓度的变化与体重反弹相关（分别为r = -0.299，P = 0.030；r = -0.274，P = 0.047；r = 0.357，P = 0.008）。它们共同解释了体重反弹变化的28%（r² = 0.532）。饮食减肥引起的ACE活性、FFA和RBP4的变化独立地有助于体重反弹的预测。
