Raab W P
Allergy Clinic 'City', Vienna, Austria.
J Int Med Res. 1990;18 Suppl 3:2C-7C.
A well-tanned skin is currently regarded as a sign of fitness, youth and health, with people increasingly exposing their skin to the sun and using tanning accelerators, such as psoralens, but exposure to ultraviolet B (UVB) radiation from the sun causes extrinsic ageing of the skin. The minimal erythema dose is rarely exceeded but the UVB dose that brings about irrepairable DNA damage leading to photodamage is lower. Growing numbers of patients, therefore, have prematurely aged skin with pigmented spots, dryness, itchiness and wrinkles. These symptoms are more than just of cosmetic concern. It is known that epitheliomas frequently develop in photodamaged skin; consequently, this skin requires medical treatment. Prophylactic measures should be taken from childhood, but an effective treatment for already damaged skin is topically applied tretinoin, which should be used with a mild skin cleansing and skin care programme.
目前，晒得黝黑的皮肤被视为健康、年轻的标志，人们越来越多地让皮肤暴露在阳光下，并使用诸如补骨脂素等晒黑促进剂，但来自太阳的紫外线B（UVB）辐射会导致皮肤出现外源性老化。很少会超过最小红斑剂量，但导致不可修复的DNA损伤从而引起光损伤的UVB剂量更低。因此，越来越多的患者皮肤过早老化，出现色素沉着、干燥、瘙痒和皱纹。这些症状不仅仅是美容方面的问题。众所周知，上皮瘤经常在光损伤的皮肤上发生；因此，这种皮肤需要医学治疗。预防措施应从儿童时期开始，但对于已经受损的皮肤，有效的治疗方法是局部应用维甲酸，同时应配合温和的皮肤清洁和皮肤护理方案。
