Brambs H J, Juchems M
Klinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Ulm, Steinhövelstrasse 9, Ulm, Germany.
Chirurg. 2012 Feb;83(2):116-22. doi: 10.1007/s00104-011-2182-9.
The intraductal papillary mucinous neoplasm (IPMN) is the most frequent cystic neoplasm of the pancreas. Due to the widespread use of cross-sectional imaging IPMN is being incidentally recognized with increasing frequency. The most common type is branch- duct IPMN which occurs multifocally in about 20-30%. Patients with IPMN may present with symptoms resembling chronic pancreatitis and episodes of acute pancreatitis are increasingly being reported which usually have a mild course. The most important diagnostic technique is contrast-enhanced multidetector computed tomography (MDCT), which most frequently allows the differentiation from other cystic lesions and enables the attribution to branch duct or main duct IPMN. Magnetic resonance imaging (MRI) in combination with magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound are superior in depicting the fine architecture of cystic tumors. Particularly for evaluation of malignant transformation and extent of malignant disease, high resolution imaging is essential. Whereas main duct IPMN is an indication for resection therapy for small and asymptomatic branch duct IPMN periodic surveillance at 6-12 month intervals is recommended.
导管内乳头状黏液性肿瘤(IPMN)是胰腺最常见的囊性肿瘤。由于横断面成像的广泛应用,IPMN被偶然发现的频率越来越高。最常见的类型是分支导管IPMN,约20%-30%为多灶性发生。IPMN患者可能出现类似慢性胰腺炎的症状,且急性胰腺炎发作的报道越来越多,其病程通常较轻。最重要的诊断技术是对比增强多层螺旋计算机断层扫描(MDCT),它最常能与其他囊性病变相鉴别,并能区分是分支导管还是主胰管IPMN。磁共振成像(MRI)结合磁共振胰胆管造影(MRCP)和内镜超声在显示囊性肿瘤的精细结构方面更具优势。特别是对于评估恶性转化和恶性疾病的范围,高分辨率成像至关重要。主胰管IPMN是手术治疗的指征,对于小的无症状分支导管IPMN,建议每隔6-12个月进行定期监测。