Stoltenberg Scott F, Lehmann Melissa K, Anderson Cynthia, Nag Parthasarathi, Anagnopoulos Cheryl
Behavior Genetics Laboratory, Department of Psychology, University of Nebraska-Lincoln Lincoln, NE, USA.
Front Genet. 2011 Jun 13;2:33. doi: 10.3389/fgene.2011.00033. eCollection 2011.
The factors that influence individual differences in decision making are not yet fully characterized, but convergent evidence is accumulating that implicates serotonin (5-HT) system function. Therefore, both genes and environments that influence serotonin function are good candidates for association with risky decision making. In the present study we examined associations between common polymorphisms in the serotonin transporter gene (SLC6A4; 5-HTTLPR and rs25531), the experience of childhood trauma and decision making on the Iowa gambling task (IGT) in 391 (64.5% female) healthy Caucasian adults. Homozygosity for the 5-HTTLPR L allele was associated with riskier decision making in the first block of 20 trials (i.e., decision making under ambiguity, p = 0.004). In addition, mean IGT performance was significantly worse in blocks 3-5 (i.e., decision making under risk, p ≤ 0.05) for those participants who reported experiencing higher levels of childhood trauma. Our findings add to the growing evidence that genetic variation in the 5-HT system is associated with individual differences in decision making under ambiguity; and we report that the experience of childhood trauma is associated with relatively poor decision making under risk.
影响决策个体差异的因素尚未完全明确，但越来越多的证据表明血清素（5-HT）系统功能与之相关。因此，影响血清素功能的基因和环境都是与风险决策相关联的良好候选因素。在本研究中，我们检测了391名（64.5%为女性）健康白种成年人中血清素转运体基因（SLC6A4；5-HTTLPR和rs25531）的常见多态性、童年创伤经历与爱荷华赌博任务（IGT）决策之间的关联。在20次试验的第一个区块中，5-HTTLPR L等位基因的纯合性与更具风险的决策相关（即在模糊情境下的决策，p = 0.004）。此外，报告童年创伤水平较高的参与者在第3 - 5个区块中的IGT平均表现显著较差（即在风险情境下的决策，p≤0.05）。我们的研究结果进一步证明，5-HT系统的基因变异与模糊情境下决策的个体差异相关；并且我们报告童年创伤经历与风险情境下相对较差的决策相关。
