Tago Yoshiyuki, Wei Min, Ishii Naomi, Kakehashi Anna, Wanibuchi Hideki
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
J Toxicol Pathol. 2010 Dec;23(4):245-51. doi: 10.1293/tox.23.245. Epub 2010 Dec 16.
Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study.
问荆，通常被称为田问荆，有作为一种新的功能性食品成分的潜力。然而，关于其副作用的信息很少，且问荆的一般毒性尚未得到详细研究。在本研究中，我们评估了在雄性和雌性F344大鼠的饮食中以0%、0.3%、1%和3%的剂量给药13周的影响。根据临床症状、体重、尿液分析、血液学和血清生化数据以及器官重量，未检测到毒性。显微镜检查未发现与治疗相关的组织病理学病变。总之，在本研究条件下，F344大鼠两性问荆的未观察到有害作用水平（NOAEL）均确定为大于3%（雄性和雌性分别为：>1.79 g/kg体重/天和>1.85 g/kg体重/天）。
