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使用重组近交系和贝叶斯定理进行双基因座连锁分析。

Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.

作者信息

Neumann P E

机构信息

Department of Neurology, Children's Hospital, Boston, Massachusetts.

出版信息

Genetics. 1990 Sep;126(1):277-84. doi: 10.1093/genetics/126.1.277.

DOI:10.1093/genetics/126.1.277
PMID:2227386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1204132/
Abstract

Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. The currently available statistical tests of linkage using data derived from the study of RI strains, including a previous Bayesian analysis, have not been stringent enough guides for conclusions about linkage. In this paper, the probability of linkage was estimated using Bayes' theorem. Tables are presented that give the probability of linkage in sets of up to 30 RI strains and the critical values of i (the number of recombinants) in sets of up to 100 RI strains. Several means of increasing the power of RI strains in linkage analysis are discussed.

摘要

重组近交（RI）品系在连锁分析和基因定位中很有用。目前使用来自RI品系研究的数据进行连锁分析的统计检验，包括之前的贝叶斯分析，对于连锁结论来说都不够严格。在本文中，使用贝叶斯定理估计连锁概率。给出了表格，这些表格给出了多达30个RI品系组中连锁的概率以及多达100个RI品系组中i（重组体数量）的临界值。还讨论了提高RI品系在连锁分析中效能的几种方法。

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本文引用的文献

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