使用重组近交系和贝叶斯定理进行双基因座连锁分析。
Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
作者信息
Neumann P E
机构信息
Department of Neurology, Children's Hospital, Boston, Massachusetts.
出版信息
Genetics. 1990 Sep;126(1):277-84. doi: 10.1093/genetics/126.1.277.
Abstract
Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. The currently available statistical tests of linkage using data derived from the study of RI strains, including a previous Bayesian analysis, have not been stringent enough guides for conclusions about linkage. In this paper, the probability of linkage was estimated using Bayes' theorem. Tables are presented that give the probability of linkage in sets of up to 30 RI strains and the critical values of i (the number of recombinants) in sets of up to 100 RI strains. Several means of increasing the power of RI strains in linkage analysis are discussed.
摘要
重组近交（RI）品系在连锁分析和基因定位中很有用。目前使用来自RI品系研究的数据进行连锁分析的统计检验，包括之前的贝叶斯分析，对于连锁结论来说都不够严格。在本文中，使用贝叶斯定理估计连锁概率。给出了表格，这些表格给出了多达30个RI品系组中连锁的概率以及多达100个RI品系组中i（重组体数量）的临界值。还讨论了提高RI品系在连锁分析中效能的几种方法。
相似文献
1
Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.使用重组近交系和贝叶斯定理进行双基因座连锁分析。
Genetics. 1990 Sep;126(1):277-84. doi: 10.1093/genetics/126.1.277.
2
Three-locus linkage analysis using recombinant inbred strains and Bayes' theorem.使用重组近交系和贝叶斯定理进行三位点连锁分析。
Genetics. 1991 Jul;128(3):631-8. doi: 10.1093/genetics/128.3.631.
3
Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses.使用重组近交系和回交进行连锁分析的统计学考量。
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1423-7. doi: 10.1073/pnas.83.5.1423.
4
Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains.基于重组近交系分析的基因连锁估计的置信限
J Hered. 1985 Nov-Dec;76(6):436-40. doi: 10.1093/oxfordjournals.jhered.a110140.
5
Useful probability considerations in genetics: the goat problem with tigers and other applications of Bayes' theorem.遗传学中的有用概率考量：带老虎的山羊问题及贝叶斯定理的其他应用
Eur J Pediatr. 2006 May;165(5):299-305. doi: 10.1007/s00431-005-0039-2. Epub 2006 Feb 7.
6
A Bayesian approach to replication of linkage findings.一种用于连锁研究结果复制的贝叶斯方法。
Genet Epidemiol. 1999;17 Suppl 1:S749-54. doi: 10.1002/gepi.13701707123.
7
[Bayesian statistics-based method for genetic linkage analysis].基于贝叶斯统计的基因连锁分析方法
Yi Chuan. 2006 Sep;28(9):1117-22. doi: 10.1360/yc-006-1117.
8
Use of recombinant inbred strains to map genes of aging.利用重组近交系定位衰老相关基因。
Genetica. 1993;91(1-3):151-65. doi: 10.1007/BF01435995.
9
Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains.使用重组近交系小鼠品系进行数量性状基因座（QTL）定位研究的I型和II型错误率。
Behav Genet. 1996 Mar;26(2):149-60. doi: 10.1007/BF02359892.
10
Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice.利用重组近交系小鼠对多基因性状进行连锁分析的推断。
Behav Genet. 1992 Nov;22(6):665-76. doi: 10.1007/BF01066637.
引用本文的文献
1
Characterizing uncertainty in high-density maps from multiparental populations.表征多亲群体高密度图谱中的不确定性。
Genetics. 2014 Sep;198(1):117-28. doi: 10.1534/genetics.114.167577.
2
Criteria to optimize designs for detection and estimation of linkage between marker loci from segregating populations containing several families.优化设计以检测和估计含有多个家系的分离群体中标记位点之间连锁的标准。
Theor Appl Genet. 1993 Apr;86(2-3):269-80. doi: 10.1007/BF00222088.
3
Maximum-likelihood models for mapping genetic markers showing segregation distortion. 1. Backcross populations.最大似然模型用于映射显示分离失真的遗传标记。1. 回交群体。
Theor Appl Genet. 1995 Jan;90(1):73-80. doi: 10.1007/BF00220998.
4
A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.一种指导小鼠甲基化修饰位点Ssm1活性的顺式作用元件。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10763-8. doi: 10.1073/pnas.95.18.10763.
5
Mapping genes controlling hematocrit in the spontaneously hypertensive rat.定位自发性高血压大鼠中控制血细胞比容的基因。
Mamm Genome. 1997 Jun;8(6):387-9. doi: 10.1007/s003359900452.
6
A genetic linkage map of the rat derived from recombinant inbred strains.一张源自重组近交系的大鼠遗传连锁图谱。
Mamm Genome. 1996 Feb;7(2):117-27. doi: 10.1007/s003359900031.
7
Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene.对嗜肺军团菌感染的天然抵抗力：Lgn1 易感基因的染色体定位。
Mamm Genome. 1995 Aug;6(8):540-5. doi: 10.1007/BF00356173.
8
Genomic mapping of intracisternal A-particle proviral elements.脑内A颗粒前病毒元件的基因组图谱
Mamm Genome. 1993;4(2):69-77. doi: 10.1007/BF00290429.
9
A Macintosh program for storage and analysis of experimental genetic mapping data.一个用于存储和分析实验性基因图谱数据的麦金塔程序。
Mamm Genome. 1993;4(6):303-13. doi: 10.1007/BF00357089.
10
Strain distribution patterns for 50 SSLP markers in the murine AKXL recombinant inbred set.小鼠AKXL重组近交系中50个简单序列长度多态性（SSLP）标记的菌株分布模式。
Mamm Genome. 1994 Mar;5(3):189-90. doi: 10.1007/BF00352356.
本文引用的文献
1
Inbreeding and Linkage.近亲繁殖与连锁
Genetics. 1931 Jul;16(4):357-74. doi: 10.1093/genetics/16.4.357.
2
Location of Ly-7 on mouse chromosome 12.Ly-7在小鼠12号染色体上的定位。
Immunogenetics. 1984;19(6):539-43. doi: 10.1007/BF00403445.
3
Strategies for multilocus linkage analysis in humans.人类多位点连锁分析策略。
Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6. doi: 10.1073/pnas.81.11.3443.
4
Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes.重组近交系：有助于寻找组织相容性及其他基因的身份、连锁关系和功能。
Transplantation. 1971 Mar;11(3):325-7. doi: 10.1097/00007890-197103000-00013.
5
Recombinant inbred lines: value in the genetic analysis of biochemical variants.重组近交系：在生化变异体遗传分析中的价值。
Science. 1973 Sep 28;181(4106):1249-52. doi: 10.1126/science.181.4106.1249.
6
Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses.使用重组近交系和回交进行连锁分析的统计学考量。
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1423-7. doi: 10.1073/pnas.83.5.1423.
7
A linkage map of mouse chromosome 12: localization of Igh and effects of sex and interference on recombination.小鼠第12号染色体的连锁图谱：免疫球蛋白重链基因（Igh）的定位以及性别和干涉对重组的影响
Genetics. 1988 Dec;120(4):1073-83. doi: 10.1093/genetics/120.4.1073.
8
Mapping to molecular resolution in the T to H-2 region of the mouse genome with a nested set of meiotic recombinants.利用一组嵌套的减数分裂重组体将小鼠基因组的T到H-2区域定位到分子分辨率水平。
Proc Natl Acad Sci U S A. 1989 Jan;86(1):222-6. doi: 10.1073/pnas.86.1.222.
9
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map.绘制人类复杂遗传性状图谱：利用完整的RFLP连锁图谱的新方法
Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:49-62. doi: 10.1101/sqb.1986.051.01.007.
10
False start on manic depression.躁郁症的误诊开端。
Nature. 1989 Nov 16;342(6247):222. doi: 10.1038/342222a0.
Zotero 插件