Pravenec M, Gauguier D, Schott J J, Buard J, Kren V, Bílá V, Szpirer C, Szpirer J, Wang J M, Huang H, St Lezin E, Spence M A, Flodman P, Printz M, Lathrop G M, Vergnaud G, Kurtz T W
Institute of Physiology, Czech Academy of Sciences, Prague.
Mamm Genome. 1996 Feb;7(2):117-27. doi: 10.1007/s003359900031.
We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.
我们通过分析从自发性高血压大鼠和布朗-挪威大鼠衍生而来的大量重组近交系（HXB和BXH重组近交系）中500个遗传标记的品系分布模式，构建了大鼠的遗传连锁图谱。其中454个标记可被定位到特定染色体上，据估计，已定位标记覆盖的基因组长度为1151厘摩。通过纳入多种形态学、生物化学、免疫遗传学和分子标记，当前图谱整合并扩展了现有的连锁数据，应有助于在HXB和BXH重组近交系中进行大鼠基因定位以及对高血压和其他感兴趣的复杂表型的遗传学研究。
