Centro di Riferimento Oncologico - IRCCS, National Cancer Institute, 33081, Aviano, Italy.
Br J Cancer. 2012 Feb 28;106(5):966-9. doi: 10.1038/bjc.2012.2. Epub 2012 Jan 24.
Ocular adnexal marginal zone B-cell lymphoma (OAMZL) has been associated with Chlamydophila psittaci, an infection that may be transmitted by carrier animals. However, it is still unclear whether exposure to animals affects the risk of OAMZL in comparison with other lymphoma histotypes. We therefore investigated the role of professional and/or domestic exposures to animals in the occurrence of OAMZL, as compared with other types of lymphoma.
A hospital-based case-control study was carried out on 43 consecutive OAMZL patients (cases) and 87 consecutive patients with nodal non-Hodgkin's lymphomas (NHLs; controls). Multiple logistic regression (MLR) odds ratios (ORs), and 95% confidence intervals (CIs) were used to estimate the association between exposures to animals and OAMZL risk.
A higher proportion of cases reported a lifetime exposure to household animals (79.1% vs 64.4% among controls), with a non-statistical significant MLR-OR of 2.18 (95% CI: 0.85-5.62). The OAMZL cases more frequently reported a history of occupation in breeding and/or slaughtering than controls (34.9% vs 6.9%), with an overall increased risk of 7.69 (95%CI: 2.65-22.34).
These results indicate that, compared with nodal NHLs, the risk of OAMZL is markedly increased by contact with animals, particularly by occupational exposures.
眼附属器边缘区 B 细胞淋巴瘤（OAMZL）与鹦鹉热衣原体有关，这种感染可能通过带菌动物传播。然而，与其他淋巴瘤组织类型相比，动物接触是否会影响 OAMZL 的发病风险仍不清楚。因此，我们研究了与动物的职业和/或家庭接触在 OAMZL 发生中的作用，与其他类型的淋巴瘤相比。
对 43 例连续 OAMZL 患者（病例）和 87 例连续结外非霍奇金淋巴瘤（NHL）患者（对照组）进行了基于医院的病例对照研究。采用多变量逻辑回归（MLR）比值比（OR）和 95%置信区间（CI）来估计动物暴露与 OAMZL 风险之间的关联。
报告有终生接触家养动物的病例比例较高（79.1%比对照组的 64.4%），MLR-OR 非统计学显著为 2.18（95%CI：0.85-5.62）。OAMZL 病例更频繁地报告有在养殖和/或屠宰行业工作的病史，比对照组（34.9%比 6.9%），总体风险增加 7.69（95%CI：2.65-22.34）。
这些结果表明，与结外 NHL 相比，与动物接触会显著增加 OAMZL 的风险，尤其是职业暴露。
