冠状动脉粥样硬化斑块中微生物的患病率：一项系统评价和荟萃分析。
Prevalence of Microorganisms in Atherosclerotic Plaques of Coronary Arteries: A Systematic Review and Meta-Analysis.
作者信息
Razeghian-Jahromi Iman, Elyaspour Zahra, Zibaeenezhad Mohammad Javad, Hassanipour Soheil
机构信息
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
出版信息
Evid Based Complement Alternat Med. 2022 Dec 1;2022:8678967. doi: 10.1155/2022/8678967. eCollection 2022.
BACKGROUND
In this systematic review and meta-analysis, the existence of pathogens in atherosclerotic plaques of coronary arteries was investigated in coronary arteries diseases (CAD) patients.
METHODS
This study was designed and implemented up to 31 August 2020. The findings present according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) checklist. Two independent reviewers (I.RJ and S.H) performed a comprehensive search on four different English databases including PubMed, ISI, Scopus, and Embase. In order to assess the quality of the articles, a checklist prepared by The Joanna Briggs Institute (JBI) was used.
RESULTS
Finally, 44 studies were selected. The prevalence of different microorganisms in coronary arteries were as follows: (46.2%), (43.0%), (42.8%), (29.1%), (18.9%), virus type 1 (5.9%), (42.6%), (47.6%), (43.7%), and (32.9%).
CONCLUSION
Based on the result of this meta-analysis, and are the most common microorganisms in atherosclerotic plaques of coronary arteries and may have an important role in the development of atherosclerosis.
背景
在这项系统评价和荟萃分析中，对冠状动脉疾病（CAD）患者冠状动脉粥样硬化斑块中病原体的存在情况进行了调查。
方法
本研究设计并实施至2020年8月31日。研究结果按照PRISMA（系统评价和荟萃分析优先报告项目）清单呈现。两名独立审阅者（I.RJ和S.H）对包括PubMed、ISI、Scopus和Embase在内的四个不同英文数据库进行了全面检索。为了评估文章质量，使用了乔安娜·布里格斯研究所（JBI）编制的清单。
结果
最终，选取了44项研究。冠状动脉中不同微生物的患病率如下：（46.2%），（43.0%），（42.8%），（29.1%），（18.9%），1型病毒（5.9%），（42.6%），（47.6%），（43.7%），以及（32.9%）。
结论
基于这项荟萃分析的结果，和是冠状动脉粥样硬化斑块中最常见的微生物，可能在动脉粥样硬化的发展中起重要作用。
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