Tinga D J, Timmer P R, Bouma J, Aalders J G
Department of Obstetrics and Gynecology, University Hospital, Groningen, The Netherlands.
Gynecol Oncol. 1990 Nov;39(2):175-80. doi: 10.1016/0090-8258(90)90428-n.
From January 1, 1970, to December 31, 1985, 51 patients with stage IB (FIGO) carcinoma of the cervix with lymph node metastases were treated at the University Hospital, Groningen, The Netherlands. The survival rate was 54% and the average duration of follow-up was 78 months (range 47-132). Important clinical variables for survival were investigated retrospectively: the survival rate in patients with a single lymph node metastasis (with tumor confined to the node itself) (n = 23) appeared to be much better than that of patients with multiple node involvement and/or single nodes with extranodular tumor infiltration (n = 28); survival was 85 and 24%, respectively (P less than 0.001). The same applied to patients with only occult lymph node involvement: the survival rate in patients with occult involvement of the hypogastric, external iliac, or obturator nodes was 87% in 19 patients with a single metastasis and 53% in 15 patients with multiple node involvement (P less than 0.02). The survival rate in 8 patients with adenomatous histological components was 42%. In 42 patients with squamous cell carcinoma, the survival rate was 56%. This difference was not statistically significant. Treatment complications and the effect of treatment on the site of recurrence were investigated.
1970年1月1日至1985年12月31日期间，荷兰格罗宁根大学医院对51例FIGO分期为IB期且伴有淋巴结转移的宫颈癌患者进行了治疗。生存率为54%，平均随访时间为78个月（范围47 - 132个月）。对影响生存的重要临床变量进行了回顾性研究：单个淋巴结转移（肿瘤局限于淋巴结本身）的患者（n = 23）的生存率明显高于多组淋巴结受累和/或伴有结外肿瘤浸润的单个淋巴结患者（n = 28）；生存率分别为85%和24%（P < 0.001）。仅隐匿性淋巴结受累的患者情况也是如此：19例单个转移灶的患者中，下腹、髂外或闭孔淋巴结隐匿受累的患者生存率为87%，15例多组淋巴结受累的患者生存率为53%（P < 0.02）。8例具有腺瘤组织学成分的患者生存率为42%。42例鳞状细胞癌患者的生存率为56%。这种差异无统计学意义。对治疗并发症以及治疗对复发部位的影响进行了研究。
