Ismail S M, Walker S M
Department of Histopathology and Obstetrics and Gynaecology, University Hospital of Wales, Cardiff, UK.
Histopathology. 1990 Aug;17(2):159-63. doi: 10.1111/j.1365-2559.1990.tb00688.x.
A woman with Gorlin's syndrome who had become pregnant following clomiphene therapy presented in early pregnancy with bilateral ovarian sclerosing stromal tumours which were associated with profound virilization. Pre- and post-operative hormone profiles indicated androgen production by the tumours. Ovarian sclerosing stromal tumours have not previously been reported as occurring bilaterally or in association with Gorlin's syndrome. We discuss the questions raised by this unusual case regarding the pathogenesis of ovarian stromal neoplasms.
一位患有戈林综合征的女性在接受克罗米芬治疗后怀孕，孕早期出现双侧卵巢硬化性间质瘤，并伴有严重的男性化。术前和术后的激素水平表明肿瘤产生雄激素。此前尚未有双侧卵巢硬化性间质瘤或与戈林综合征相关的报道。我们讨论了这一罕见病例引发的关于卵巢间质肿瘤发病机制的问题。
