Vajpayee Vaishali, Lee Sun Mi, Park Joeng Woo, Dubey Abhishek, Kim Hyunuk, Cook Timothy R, Stang Peter J, Chi Ki-Whan
Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
Organometallics. 2013 Mar 25;32(6):1563-1566. doi: 10.1021/om301174s.
Two new supramolecular coordination complexes (SCCs), were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, , with dipyridyl and tripyridyl donors, respectively. As part of a growing library of anticancer-active Ru-based SCCs, metalla-prism selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC values as low as 8.41 μM for MCF7 cells, as determined from MTS assays.
通过一种新型双苯并咪唑桥联的钌受体分别与二吡啶和三吡啶供体的自组装，获得了两种新型超分子配位络合物（SCCs）。作为不断增加的具有抗癌活性的钌基SCCs库的一部分，金属棱柱相对于顺铂对一系列癌细胞系选择性地表现出高细胞毒性，根据MTS分析测定，MCF7细胞的IC值低至8.41μM。
