Fácila Lorenzo, Morillas Pedro, Quiles Juan, Soria Federico, Cordero Alberto, Mazón Pilar, Anguita Manuel, Martín-Luengo Cándido, Gonzalez-Juanatey Jose Ramón, Bertomeu Vicente
Lorenzo Fácila, Department of Cardiology, Consorcio Hospitalario General de Valencia, 46014 Valencia, Spain.
World J Cardiol. 2012 Jan 26;4(1):15-9. doi: 10.4330/wjc.v4.i1.15.
To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors.
Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year.
There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009).
A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up.
探讨静息心率在急性冠状动脉综合征（ACS）患者中的预后意义，独立于其他已知因素。
纳入年龄40岁及以上、因急性冠状动脉综合征（ACS）入住参与急性冠状动脉综合征患者外周动脉疾病患病率（PAMISCA）研究的94家医院之一的患者。根据静息心率（HR≥或<70次/分钟）将患者分为两组。在1年的随访期内记录并发症情况。
共分析了1054例ACS患者（43.5%为ST段抬高型，56.5%为非ST段抬高型）。平均年龄为66.6±11.7岁，70.6%为男性，29.4%为女性。随访期间，HR≥70次/分钟组有更多患者因心力衰竭住院，且死亡率也更高。在多变量分析中，静息心率≥70次/分钟与随访期间的总体死亡率独立相关（风险比2.5；95%置信区间，1.26 - 4.97，P = 0.009）。
ACS存活患者静息心率≥70次/分钟是随访期间发生心血管事件高风险的一个指标。
