Vo Thanh-Sang, Ngo Dai-Hung, Kim Se-Kwon
Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan, Republic of Korea.
Inflamm Allergy Drug Targets. 2012 Apr;11(2):90-101. doi: 10.2174/187152812800392797.
The inflammatory and allergic diseases are among the most common diseases all over the world. The prevalence, severity, and complexity of these diseases are rapidly rising and considerably adding to the burden of healthcare costs. Although the synthetic and combinatorial chemistry have given rise to notable successes in the development of novel anti-inflammatory and anti-allergic drugs, but the extensive clinical use has led to the diverse and undesirable side effects. Meanwhile, the perceived value of natural products in the treatment of these diseases has yet to be fully explored. Thus, the extensive studies of alternative anti-inflammatory and anti-allergic drugs from natural products are essential. Notably, marine algae have been utilized in food products as well as in pharmaceutical products due to their biological activities and health benefit effects. Recently, marine algae have attracted a special interest as great sources of antiinflammatory and anti-allergic agents. This review presents an overview of potential anti-inflammatory and anti-allergic agents derived from marine algae and their promising applications in inflammation and allergy therapy.
炎症性和过敏性疾病是全球最常见的疾病之一。这些疾病的患病率、严重程度和复杂性正在迅速上升，大大增加了医疗成本负担。尽管合成化学和组合化学在新型抗炎和抗过敏药物的开发中取得了显著成功，但广泛的临床应用导致了各种不良副作用。与此同时，天然产物在治疗这些疾病中的潜在价值尚未得到充分探索。因此，广泛研究来自天然产物的替代抗炎和抗过敏药物至关重要。值得注意的是，由于其生物活性和健康益处，海藻已被用于食品和药品中。最近，海藻作为抗炎和抗过敏剂的重要来源引起了特别关注。本文综述了源自海藻的潜在抗炎和抗过敏剂及其在炎症和过敏治疗中的应用前景。
