Department of Food Science and Technology, Faculty of Agricultural Engineering and Technology, IPB University (Bogor Agricultural University), West Java 16680, Indonesia.
Southeast Asian Food and Agricultural Science Technology (SEAFAST) Center, IPB University (Bogor Agricultural University), West Java 16680, Indonesia.
Mar Drugs. 2021 Apr 28;19(5):252. doi: 10.3390/md19050252.
brown seaweed is reported to exhibit several biological activities which promote human health, such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, and antioxidant activity. This study aimed to investigate the anti-inflammatory and antioxidant activity of crude lipid extracts of obtained from four different coastal areas in Indonesia, namely Awur Bay-Jepara (AB), Pari Island-Seribu Islands (PI), Sayang Heulang Beach-Garut (SHB), and Ujung Genteng Beach-Sukabumi (UGB). Results showed that treatment of RAW 264.7 macrophage cells with UGB and AB crude lipid extracts (12.5-50 µg/mL) significantly suppressed the nitric oxide production after lipopolysaccharide stimulation, both in pre-incubated and co-incubated cell culture model. The anti-inflammatory effect was most marked in the pre-incubated cell culture model. Both two crude lipid extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and high ferric reducing antioxidant power, which were amounted to 36.93-37.87 µmol Trolox equivalent/g lipid extract and 681.58-969.81 µmol FeSO/g lipid extract, respectively. From this study, we can conclude that crude lipid extract of tropical can be further developed as a source of anti-inflammatory and antioxidant agent.
褐藻被报道具有多种促进人类健康的生物活性，如抗癌、抗菌、抗糖尿病、抗炎和抗氧化活性。本研究旨在研究从印度尼西亚四个不同沿海地区获得的 的粗脂质提取物的抗炎和抗氧化活性，分别是 Awur Bay-Jepara（AB）、Pari 岛-Seribu 群岛（PI）、Sayang Heulang 海滩-Garut（SHB）和 Ujung Genteng 海滩-Sukabumi（UGB）。结果表明，用 UGB 和 AB 粗脂质提取物（12.5-50 µg/mL）处理 RAW 264.7 巨噬细胞后，显著抑制了脂多糖刺激后的一氧化氮产生，无论是在预孵育和共孵育细胞培养模型中。抗炎作用在预孵育细胞培养模型中最为显著。两种粗脂质提取物均表现出 2,2-二苯基-1-苦基肼自由基清除活性和高铁还原抗氧化能力，分别相当于 36.93-37.87 µmol Trolox 当量/g 脂质提取物和 681.58-969.81 µmol FeSO/g 脂质提取物。从这项研究中，我们可以得出结论，热带 的粗脂质提取物可以进一步开发为抗炎和抗氧化剂的来源。
