Nat Genet. 2012 Jan 27;44(2):116-8. doi: 10.1038/ng.1082.
The sequencing of the genome and transcriptome of Schistosoma haematobium, a highly prevalent blood fluke and human parasite with a proven link to malignant bladder cancer, marks the 160(th) anniversary of its discovery as the first schistosome known to infect humans. Comparative genomic analyses of S. haematobium and the more prevalent human-schistosomiasis pathogens (Schistosoma mansoni and Schistosoma japonicum) identified both shared and distinct genomic features.
曼氏血吸虫基因组和转录组测序,这种高度流行的血吸虫和人类寄生虫已被证明与膀胱癌恶性肿瘤有关,标志着它作为第一种已知感染人类的血吸虫被发现的 160 周年。曼氏血吸虫与更为流行的人类血吸虫病病原体(曼氏血吸虫和日本血吸虫)的比较基因组分析,确定了两者共享和独特的基因组特征。