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与人类癌症相关的血吸病虫基因组。

The genome of a blood fluke associated with human cancer.

出版信息

Nat Genet. 2012 Jan 27;44(2):116-8. doi: 10.1038/ng.1082.

DOI:10.1038/ng.1082
PMID:22281765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3718006/
Abstract

The sequencing of the genome and transcriptome of Schistosoma haematobium, a highly prevalent blood fluke and human parasite with a proven link to malignant bladder cancer, marks the 160(th) anniversary of its discovery as the first schistosome known to infect humans. Comparative genomic analyses of S. haematobium and the more prevalent human-schistosomiasis pathogens (Schistosoma mansoni and Schistosoma japonicum) identified both shared and distinct genomic features.

摘要

曼氏血吸虫基因组和转录组测序,这种高度流行的血吸虫和人类寄生虫已被证明与膀胱癌恶性肿瘤有关,标志着它作为第一种已知感染人类的血吸虫被发现的 160 周年。曼氏血吸虫与更为流行的人类血吸虫病病原体(曼氏血吸虫和日本血吸虫)的比较基因组分析,确定了两者共享和独特的基因组特征。

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Whole-genome sequence of Schistosoma haematobium.曼氏血吸虫全基因组序列。
Nat Genet. 2012 Jan 15;44(2):221-5. doi: 10.1038/ng.1065.
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Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.血吸虫比较基因组学:整合基因组结构、寄生虫生物学和驱虫药发现。
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Effects of Polymorphisms in the SjSP-13 Gene of on Its Diagnostic Efficacy and Immunogenicity.日本血吸虫 SjSP-13 基因多态性对其诊断效能和免疫原性的影响。
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The genome of the blood fluke Schistosoma mansoni.曼氏血吸虫的基因组。
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