Department of Gastroenterology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan.
Gastric Cancer. 2012 Jul;15(3):331-4. doi: 10.1007/s10120-012-0141-x. Epub 2012 Jan 27.
A combination of the detection of serum anti-Helicobacter pylori antibody and measurement of the level of serum pepsinogens (PG)s, known as the ABC method, has been used in screening for gastric cancer. The ABC method has been shown to be useful in urban and/or younger populations. The aim of this study was to assess whether this method is applicable for an agricultural population with a high incidence of gastric cancer. In all, 1048 healthy adults (401 men and 647 women) who participated in a mass survey in April 2005 were examined. Their serum samples were tested to determine the prevalence of anti-H. pylori antibody, and the levels of PG I and PG II were also measured to assess the presence of atrophic gastritis. Of the elderly subjects born before 1940, 59.4% were classified into groups C and D, with a high risk for gastric cancer, and only 22.7% were classified into group A, with the lowest risk. Of the middle-aged subjects born in the 1940s and the 1950s, 66.5% were classified into groups B-D. If the ABC method is performed in the mass screening for gastric cancer in this population, a large number of subjects will be identified for further examinations. The applicability of the ABC method should be evaluated before use in the screening for gastric cancer, particularly in an aging population with a high prevalence of H. pylori infection and atrophic gastritis.
联合检测血清抗幽门螺杆菌抗体和胃蛋白酶原（PG）水平的 ABC 法已被用于胃癌的筛查。ABC 法在城市和/或年轻人群中已被证明是有用的。本研究旨在评估该方法是否适用于胃癌高发的农业人群。共有 1048 名健康成年人（401 名男性和 647 名女性）参加了 2005 年 4 月的大规模调查，检测了他们的血清样本以确定抗 H. pylori 抗体的流行率，并测量了 PG I 和 PG II 的水平以评估萎缩性胃炎的存在。在出生于 1940 年前的老年人群中，59.4%被归类为 C 和 D 组，患胃癌的风险较高，只有 22.7%被归类为 A 组，患胃癌的风险最低。在 20 世纪 40 年代和 50 年代出生的中年人群中，66.5%被归类为 B-D 组。如果在该人群中进行胃癌的大规模筛查，将有大量的患者需要进一步检查。在用于胃癌筛查之前，应评估 ABC 法的适用性，特别是在 H. pylori 感染和萎缩性胃炎流行率较高的老龄化人群中。
