Pittsburgh Bacteriophage Institute and Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Virol. 2012 Feb;86(4):2382-4. doi: 10.1128/JVI.06870-11.
Bacteriophages are the most numerous biological entities in the biosphere, and although their genetic diversity is high, it remains ill defined. Mycobacteriophages-the viruses of mycobacterial hosts-provide insights into this diversity as well as tools for manipulating Mycobacterium tuberculosis. We report here the complete genome sequences of 138 new mycobacteriophages, which-together with the 83 mycobacteriophages previously reported-represent the largest collection of phages known to infect a single common host, Mycobacterium smegmatis mc(2) 155.
噬菌体是生物圈中数量最多的生物实体,尽管它们的遗传多样性很高,但仍然定义不明确。分枝杆菌噬菌体——分枝杆菌宿主的病毒——为这种多样性提供了深入了解,同时也为操纵结核分枝杆菌提供了工具。我们在此报告了 138 种新分枝杆菌噬菌体的完整基因组序列,加上之前报道的 83 种分枝杆菌噬菌体,这代表了已知感染单一常见宿主分枝杆菌 mc(2)155 的最大噬菌体集合。