Department of Anesthesiology, Ludwig-Maximilians-University Munich, D-80336 Munich, Germany.
J Clin Anesth. 2012 Feb;24(1):51-4. doi: 10.1016/j.jclinane.2011.03.008.
Propofol is widely used for sedating critically ill adult patients because of its rapid onset and short recovery times, even after prolonged use. Propofol may be associated with a life-threatening syndrome, propofol-related infusion syndrome (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, and rhabodomyolysis. The pathophysiology is incompletely understood. Propofol-related infusion syndrome seems to be dose-related, and it occurs generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented.
异丙酚因其起效迅速、恢复时间短而被广泛用于重症成年患者镇静，即使长期使用也是如此。异丙酚可能与一种危及生命的综合征有关，即异丙酚相关输注综合征（PRIS），其包括心力衰竭、严重代谢性酸中毒、肾衰竭和横纹肌溶解。其病理生理学尚不完全清楚。异丙酚相关输注综合征似乎与剂量有关，通常发生在长期（> 48 小时）镇静且剂量较高（> 4 mg/kg/hr）的患者中。本文介绍了一例严重颅脑损伤患者发生 PRIS 的病例。
