General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China.
School of Nursing, Jilin University, Changchun, China.
Front Immunol. 2024 Jan 16;14:1343788. doi: 10.3389/fimmu.2023.1343788. eCollection 2023.
Stroke poses a critical global health challenge, leading to substantial morbidity and mortality. Existing treatments often miss vital timeframes and encounter limitations due to adverse effects, prompting the pursuit of innovative approaches to restore compromised brain function. This review explores the potential of filamentous phages in enhancing stroke recovery. Initially antimicrobial-centric, bacteriophage therapy has evolved into a regenerative solution. We explore the diverse role of filamentous phages in post-stroke neurological restoration, emphasizing their ability to integrate peptides into phage coat proteins, thereby facilitating recovery. Experimental evidence supports their efficacy in alleviating post-stroke complications, immune modulation, and tissue regeneration. However, rigorous clinical validation is essential to address challenges like dosing and administration routes. Additionally, genetic modification enhances their potential as injectable biomaterials for complex brain tissue issues. This review emphasizes innovative strategies and the capacity of filamentous phages to contribute to enhanced stroke recovery, as opposed to serving as standalone treatment, particularly in addressing stroke-induced brain tissue damage.
中风是一个全球性的重大健康挑战，导致大量的发病率和死亡率。现有的治疗方法往往错过了关键的时间窗口，并且由于副作用而受到限制，这促使人们寻求创新的方法来恢复受损的大脑功能。本综述探讨了丝状噬菌体在增强中风恢复方面的潜力。最初以抗菌为中心，噬菌体治疗已经发展成为一种再生解决方案。我们探讨了丝状噬菌体在中风后神经恢复中的多种作用，强调它们将肽整合到噬菌体外壳蛋白中的能力，从而促进恢复。实验证据支持它们在减轻中风后并发症、免疫调节和组织再生方面的功效。然而，严格的临床验证对于解决剂量和给药途径等挑战至关重要。此外，基因修饰增强了它们作为用于复杂脑组织问题的可注射生物材料的潜力。本综述强调了创新策略和丝状噬菌体的能力，有助于增强中风恢复，而不是作为单一的治疗方法，特别是在解决中风引起的脑组织损伤方面。
