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心力衰竭的种族差异:苏格兰健康与种族关联研究(SHELS)。

Ethnic variations in heart failure: Scottish Health and Ethnicity Linkage Study (SHELS).

机构信息

Edinburgh Ethnicity and Health Research Group, Centre for Population Health Studies, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.

出版信息

Heart. 2012 Mar;98(6):468-73. doi: 10.1136/heartjnl-2011-301191. Epub 2012 Jan 27.

Abstract

OBJECTIVE

Ethnic variations in heart failure are, apparently, large (eg, up to threefold in South Asians compared with White populations in Leicestershire, UK) but data are limited and conflicting. The incidence of first occurrence of heart failure hospitalisation or death by ethnic group in Scotland was studied. DESIGN, SETTING, POPULATIONS AND OUTCOMES: A retrospective cohort study was developed of 4.65 million people using non-disclosive, computerised methods linking the Scottish 2001 census (providing ethnic group) to community death and hospital discharge/deaths data (SMR01). Annual, directly age standardised incidence rates per 100,000, incidence rate ratios (RRs) and risk ratios using Poisson regression were calculated. Ratios were multiplied by 100. Risk ratios were adjusted for age and highest education qualification. Statements of difference imply the 95% CI excludes 100 (reference), otherwise the CI is given.

RESULTS

In men, other White British (RR=86.4) and Chinese (RR=54.2) had less heart failure than White Scottish (100) populations while Pakistani men had more (RR=134.9). In women, the pattern was similar to men. Adjustment for highest educational qualification attenuated differences in risk ratios in other White British men (risk ratio=75.8 to 85.4) and women (66.2 to 74.6), made little difference to Pakistani men (146.9 to 142.1) and women (177.4 to 158.1), and augmented them in Indian men (115.4 (95% CI 93.1 to 143.0) to 131.7 (107.4 to 161.5)).

CONCLUSIONS

Ethnic variations in heart failure were important in this population setting and not abolished by adjusting for highest education, one important indicator of socioeconomic differences. The ethnic variations were substantial but did not support other studies showing 3-20-fold differences between ethnic groups.

摘要

目的

心力衰竭的种族差异显然很大(例如,与英国莱斯特郡的白人相比,南亚人高达三倍),但数据有限且相互矛盾。本研究旨在探讨苏格兰按族裔分组的心力衰竭首次住院或死亡的发生率。

设计、地点、人群和结局:采用回顾性队列研究,使用非披露式、计算机化方法,将苏格兰 2001 年人口普查(提供族裔群体)与社区死亡和住院出院/死亡数据(SMR01)进行链接,共纳入 465 万人。计算每 10 万人的年龄标准化发病率(ASIR)、发病率比(RR)和泊松回归风险比。比值乘以 100。风险比按年龄和最高教育程度进行调整。差异表述表示 95%CI 不包含 100(参照),否则给出 CI。

结果

在男性中,其他白种英国人(RR=86.4)和中国人(RR=54.2)心力衰竭的发病率低于白种苏格兰人(100),而巴基斯坦男性则更高(RR=134.9)。在女性中,情况与男性相似。调整最高教育程度后,其他白种英国男性(风险比=75.8 至 85.4)和女性(66.2 至 74.6)的风险比差异减弱,对巴基斯坦男性(146.9 至 142.1)和女性(177.4 至 158.1)的影响较小,而对印度男性(115.4(95%CI 93.1 至 143.0)至 131.7(107.4 至 161.5))的影响则增强。

结论

在这一人群中,心力衰竭的种族差异很重要,通过调整最高教育程度(社会经济差异的一个重要指标)无法消除这种差异。这些种族差异很大,但与其他研究显示的种族间 3-20 倍的差异并不一致。

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