Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA.
Chem Soc Rev. 2012 Apr 7;41(7):2885-911. doi: 10.1039/c2cs15260f. Epub 2012 Jan 27.
This critical review will present the role of nanoparticles (NPs) in the directions that are vital to the new field of nanomedicine, including imaging and drug delivery. We reflect on the physical properties that make NPs advantageous for in vivo efficacy, and review recent advances in major NP based biomedical applications. Critical questions of transport, uptake, and clearance will be discussed and illustrated through the success and opportunities of NP imaging and therapy on a photodynamic therapy (PDT) based NP system that has been developed in our lab over the past decade (540 references).
这篇评论文章将介绍纳米粒子（NPs）在纳米医学这一新领域的重要方向上的作用，包括成像和药物输送。我们反思了使 NPs 具有体内疗效优势的物理特性，并回顾了基于 NP 的主要生物医学应用的最新进展。通过讨论和说明我们实验室在过去十年中开发的基于光动力疗法（PDT）的 NP 系统的 NP 成像和治疗的成功和机会，来探讨和说明运输、摄取和清除等关键问题。（共 540 个参考文献）
