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纳米粒子在癌症中的治疗诊断应用。

Theranostic applications of nanoparticles in cancer.

机构信息

University of Lyon, F-69622, Lyon, France.

出版信息

Drug Discov Today. 2012 Sep;17(17-18):928-34. doi: 10.1016/j.drudis.2012.03.010. Epub 2012 Mar 30.

Abstract

Nanoparticles are the moieties that have undergone the most investigation in recent years for biomedical applications. They are applied in the field of oncology in the same way as in other branches of biomedical nanotechnology. Regarding cancer, nanoparticles, and especially magnetic nanoparticles, are studied for diagnosis, drug delivery, gene delivery, bioseparation, hyperthermia, phototherapy, chemotherapy, imaging mechanisms, among other uses. Different techniques are used to prepare multifunctional nanoparticles and modify nanoparticle surfaces required for different applications. This review focuses on the basic theranostic approach, the different materials used in theranostics, theranostic applications and future directions based on recent developments in these areas.

摘要

纳米粒子是近年来在生物医学应用中研究最多的部分。它们在肿瘤学领域的应用方式与生物医学纳米技术的其他分支相同。关于癌症,纳米粒子,特别是磁性纳米粒子,正在研究用于诊断、药物输送、基因输送、生物分离、热疗、光疗、化疗、成像机制等。不同的技术被用于制备多功能纳米粒子,并修饰用于不同应用的纳米粒子表面。这篇综述集中在基本的治疗诊断方法、治疗诊断中使用的不同材料、治疗诊断应用以及基于这些领域的最新发展的未来方向。

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