Dournes Gaël, Montaudon Michel, Berger Patrick, Laurent François
Department of Thoracic and Cardiovascular Imaging, CHU Bordeaux, Avenue de Magellan, 33604 Pessac, France.
J Allergy (Cairo). 2012;2012:972479. doi: 10.1155/2012/972479. Epub 2012 Jan 11.
Computed tomography (CT) is a clinical tool widely used to assess and followup asthma and chonic obstructive pulmonary disease (COPD) in humans. Strong efforts have been made the last decade to improve this technique as a quantitative research tool. Using semiautomatic softwares, quantification of airway wall thickness, lumen area, and bronchial wall density are available from large to intermediate conductive airways. Skeletonization of the bronchial tree can be built to assess its three-dimensional geometry. Lung parenchyma density can be analysed as a surrogate of small airway disease and emphysema. Since resident cells involve airway wall and lung parenchyma abnormalities, CT provides an accurate and reliable research tool to assess their role in vivo. This litterature review highlights the most recent advances made to assess asthma and COPD with CT, and also their drawbacks and the place of CT in clarifying the complex physiopathology of both diseases.
计算机断层扫描（CT）是一种临床工具，广泛用于评估和随访人类哮喘和慢性阻塞性肺疾病（COPD）。在过去十年中，人们做出了巨大努力来改进这项技术，使其成为一种定量研究工具。使用半自动软件，可以从大到中等大小的传导气道中对气道壁厚度、管腔面积和支气管壁密度进行量化。可以构建支气管树的骨架来评估其三维几何形状。肺实质密度可作为小气道疾病和肺气肿的替代指标进行分析。由于驻留细胞参与气道壁和肺实质异常，CT提供了一种准确可靠的研究工具来评估它们在体内的作用。这篇文献综述强调了用CT评估哮喘和COPD的最新进展，以及它们的缺点和CT在阐明这两种疾病复杂病理生理学方面的地位。
