产 OXA-48 型碳青霉烯酶肠杆菌科在德国医院的出现。
Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals.
机构信息
Robert Koch Institute, Nosocomial Infections, Wernigerode, Germany.
出版信息
Antimicrob Agents Chemother. 2012 Apr;56(4):2125-8. doi: 10.1128/AAC.05315-11. Epub 2012 Jan 30.
Abstract
Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.
摘要
从德国五家医院的八名患者中收集了 9 株耐碳青霉烯肠杆菌科分离株进行了研究。其中 6 株分离株产生了 OXA-48 碳青霉烯酶，3 株分离株产生了 OXA-162，它是 OXA-48 的点突变形式。两种碳青霉烯酶基因均位于 IncL/M 型可接合质粒上。插入序列 IS1999（是否被 IS1R 截断）位于所有分离株 bla(OXA-48)和 bla(OXA-162)基因的上游。脉冲场凝胶电泳分型表明，两所医院的一株产 OXA-48 的肺炎克雷伯菌菌株发生了克隆传播。
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