β2微球蛋白和新蝶呤：儿童1型人类免疫缺陷病毒感染的预测标志物？
Beta 2-microglobulin and neopterin: predictive markers for human immunodeficiency virus type 1 infection in children?
作者信息
Chan M M, Campos J M, Josephs S, Rifai N
机构信息
Department of Laboratory Medicine, Children's National Medical Center, Washington, D.C. 20010.
出版信息
J Clin Microbiol. 1990 Oct;28(10):2215-9. doi: 10.1128/jcm.28.10.2215-2219.1990.
The value of beta 2-microglobulin and neopterin concentrations in serum for early diagnosis of infants born to human immunodeficiency virus type 1 (HIV-1)-infected mothers was assessed. Concentrations of both markers were measured in serum samples from pediatric patients (Centers for Disease Control classifications P0, P1, and P2), as well as in age-matched normal subjects. Both beta 2-microglobulin and neopterin were significantly increased in HIV-1-infected symptomatic subjects (P2) compared to controls. Seventy-five percent of asymptomatic patients (P1) also had increased values. On the other hand, a significant overlap in concentrations of both markers in serum was found between controls and P0 patients. Thirty-eight percent of the P0 patients had values comparable to those of the P2 group. Persistently high concentrations of both markers in P0 patients may be indicative of HIV-1 infection.
评估了血清中β2-微球蛋白和新蝶呤浓度对1型人类免疫缺陷病毒（HIV-1）感染母亲所生婴儿早期诊断的价值。在儿科患者（疾病控制中心分类为P0、P1和P2）以及年龄匹配的正常受试者的血清样本中测量了这两种标志物的浓度。与对照组相比，HIV-1感染的有症状受试者（P2）中β2-微球蛋白和新蝶呤均显著升高。75%的无症状患者（P1）的值也有所升高。另一方面，在对照组和P0患者之间发现血清中这两种标志物的浓度有显著重叠。38%的P0患者的值与P2组相当。P0患者中这两种标志物持续高浓度可能表明HIV-1感染。
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