C. Mondino National Neurological Institute, University of Pavia, Pavia, Italy.
AOU Policlinico di Bari, Bari, Italy.
Neurol Sci. 2017 Oct;38(Suppl 2):217-224. doi: 10.1007/s10072-017-3034-2.
This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.
本文件提出了脑脊液（CSF）分析和寡克隆带（OCB）测定的指南，作为中枢神经系统神经炎症性病变的关键检测手段。这些指南是通过基于问卷调查、互联网联系以及赞助的意大利神经免疫学会（AINI）大会研讨会讨论的共识过程制定的。本指南为神经科医生和临床病理学家的交流群体提供了有关适应证疾病的必要临床信息，特别是那些在鞘内腔中存在 OCB 的疾病，还包括 CSF 分析和 OCB 测定的适应证和限制、结果解释说明以及实验室协议（附录）。
