Alidjinou Kazali, Mathieu Daniel, Colombel Jean Frédéric, François Nadine, Poulain Daniel, Sendid Boualem
Laboratoire de parasitologie-mycologie, Institut de microbiologie, Centre de biologie pathologie, CHRU de Lille.
Ann Biol Clin (Paris). 2012 Jan-Feb;70(1):89-92. doi: 10.1684/abc.2011.0654.
The prevalence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections are associated with a high morbidity and significant mortality, requiring early diagnosis and appropriate treatment but also an optimal prophylaxis in patients with high risk factors. We report a case of triple fungal infection including an invasive pulmonary aspergillosis by Aspergillus fumigatus, a candidemia by Candida albicans and a Pneumocystis pneumonia. The overall clinical picture of this patient was liver cirrhosis with medical history of immunosuppressive treatment for Crohn disease and a non-hodgkin lymphoma. There was no antifungal prophylaxis for this patient. Under treatment, the issue was unfavourable with multivisceral failure.
侵袭性真菌病的患病率正在上升,尤其是在免疫功能低下或因严重基础疾病住院的患者中。此类感染与高发病率和显著死亡率相关,需要早期诊断和适当治疗,同时也需要对高危患者进行最佳预防。我们报告一例三重真菌感染病例,包括烟曲霉引起的侵袭性肺曲霉病、白色念珠菌引起的念珠菌血症和肺孢子菌肺炎。该患者的总体临床表现为肝硬化,有因克罗恩病和非霍奇金淋巴瘤接受免疫抑制治疗的病史。该患者未进行抗真菌预防。在治疗过程中,病情发展不利,出现多脏器功能衰竭。