• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Personalized cardiovascular medicine and drug development: time for a new paradigm.

作者信息

Loscalzo Joseph

机构信息

Department of Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115-2394.

出版信息

Circulation. 2012 Jan 31;125(4):638-45. doi: 10.1161/CIRCULATIONAHA.111.089243.

DOI:10.1161/CIRCULATIONAHA.111.089243
PMID:22294708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3273851/
Abstract
摘要

相似文献

1
Personalized cardiovascular medicine and drug development: time for a new paradigm.个性化心血管医学与药物研发：新范式的时代已来。
Circulation. 2012 Jan 31;125(4):638-45. doi: 10.1161/CIRCULATIONAHA.111.089243.
2
[Innovative approach for drug discovery by targeted therapy].[通过靶向治疗进行药物发现的创新方法]
Yakugaku Zasshi. 2013;133(1):41-2. doi: 10.1248/yakushi.12-00245-f.
3
[Translational research - towards personalized medicine].[转化医学——迈向个性化医疗]
Nihon Yakurigaku Zasshi. 2013 Mar;141(3):122-5. doi: 10.1254/fpj.141.122.
4
Applications of molecular imaging in drug discovery and development process.分子影像学在药物发现和开发过程中的应用。
Curr Pharm Biotechnol. 2011 Apr;12(4):459-68. doi: 10.2174/138920111795163904.
5
Tumour-agnostic therapies.肿瘤非特异性疗法。
Nat Rev Drug Discov. 2020 Jun;19(6):383-384. doi: 10.1038/d41573-020-00015-1.
6
Review and Updates in Regenerative and Personalized Medicine, Preclinical Animal Models, and Clinical Care in Cardiovascular Medicine.再生医学与个性化医学、心血管医学临床前动物模型及临床护理的综述与更新
J Cardiovasc Transl Res. 2015 Nov;8(8):466-74. doi: 10.1007/s12265-015-9657-x. Epub 2015 Oct 9.
7
[Next generation zebrafish-based drug discovery and precision medicine].[基于斑马鱼的新一代药物发现与精准医学]
Nihon Yakurigaku Zasshi. 2019;154(2):78-83. doi: 10.1254/fpj.154.78.
8
Promise of personalized omics to precision medicine.个性化组学对精准医学的承诺。
Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):73-82. doi: 10.1002/wsbm.1198. Epub 2012 Nov 26.
9
An NIH National Center for Advancing Translational Sciences: is a focus on drug discovery the best option?美国国立卫生研究院国家推进转化科学中心：专注于药物研发是最佳选择吗？
Nat Rev Drug Discov. 2011 Jun;10(6):471. doi: 10.1038/nrd3357-c1. Epub 2011 May 20.
10
From genetics to smart watches: developments in precision cardiology.从遗传学到智能手表：精准心脏病学的发展。
Nat Rev Cardiol. 2019 Feb;16(2):72-73. doi: 10.1038/s41569-018-0149-y.

引用本文的文献

1
The MAPK/ERK signaling pathway involved in Raddeanin A induces apoptosis via the mitochondrial pathway and G2 phase arrest in multiple myeloma.雷打不变 A 通过线粒体途径和 G2 期阻滞诱导多发性骨髓瘤细胞凋亡涉及的 MAPK/ERK 信号通路。
Sci Rep. 2024 Nov 23;14(1):29061. doi: 10.1038/s41598-024-76465-z.
2
Molecular interaction networks and drug development: Novel approach to drug target identification and drug repositioning.分子相互作用网络与药物研发：药物靶点鉴定和药物重定位的新方法。
FASEB J. 2023 Jan;37(1):e22660. doi: 10.1096/fj.202201683R.
3
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology.环鸟苷酸调节药物在心血管疾病中的作用：基于机制的网络药理学。
Cardiovasc Res. 2022 Jul 20;118(9):2085-2102. doi: 10.1093/cvr/cvab240.
4
Importance of scientific collaboration in contemporary drug discovery and development: a detailed network analysis.当代药物发现和开发中科学合作的重要性：详细的网络分析。
BMC Biol. 2020 Oct 13;18(1):138. doi: 10.1186/s12915-020-00868-3.
5
Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine.网络与系统医学：欧洲科技合作组织关于开放多尺度系统医学行动的立场文件
Netw Syst Med. 2020 Jul 6;3(1):67-90. doi: 10.1089/nsm.2020.0004. eCollection 2020.
6
Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail.临床前动物研究中的外部有效性问题能否克服？为什么大多数动物模型注定会失败。
J Transl Med. 2018 Nov 7;16(1):304. doi: 10.1186/s12967-018-1678-1.
7
Machine Learning Methods Improve Prognostication, Identify Clinically Distinct Phenotypes, and Detect Heterogeneity in Response to Therapy in a Large Cohort of Heart Failure Patients.机器学习方法可改善预后，识别具有临床特征的不同表型，并检测心力衰竭患者大队列中对治疗的反应异质性。
J Am Heart Assoc. 2018 Apr 12;7(8):e008081. doi: 10.1161/JAHA.117.008081.
8
Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes.系统方法研究 HDAC 抑制剂的药理学作用揭示了 EP300 在糖尿病中的活性和调控的趋同机制。
Epigenetics. 2017;12(11):991-1003. doi: 10.1080/15592294.2017.1371892.
9
Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990-2011.以主要替代终点进行的心血管试验二十年：1990 - 2011年
J Am Heart Assoc. 2017 Mar 21;6(3):e005285. doi: 10.1161/JAHA.116.005285.
10
Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case.系统药理学与合理联合用药：以一氧化氮-环磷酸鸟苷信号通路为例及一般情况的推导
PLoS Comput Biol. 2016 Mar 17;12(3):e1004822. doi: 10.1371/journal.pcbi.1004822. eCollection 2016 Mar.

本文引用的文献

1
How were new medicines discovered?新药是如何发现的？
Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19. doi: 10.1038/nrd3480.
2
The productivity crisis in pharmaceutical R&D.制药研发的生产力危机。
Nat Rev Drug Discov. 2011 Jun;10(6):428-38. doi: 10.1038/nrd3405.
3
Controllability of complex networks.复杂网络的控制
Nature. 2011 May 12;473(7346):167-73. doi: 10.1038/nature10011.
4
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.通过肿瘤基因组分析解析黑色素瘤中 RAF 抑制治疗抵抗。
J Clin Oncol. 2011 Aug 1;29(22):3085-96. doi: 10.1200/JCO.2010.33.2312. Epub 2011 Mar 7.
5
Network medicine: a network-based approach to human disease.网络医学：一种基于网络的人类疾病研究方法。
Nat Rev Genet. 2011 Jan;12(1):56-68. doi: 10.1038/nrg2918.
6
Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.利用化学系统生物学进行药物发现：鉴定蛋白质-配体结合网络以解释CETP抑制剂的副作用
PLoS Comput Biol. 2009 May;5(5):e1000387. doi: 10.1371/journal.pcbi.1000387. Epub 2009 May 15.
7
A network view of disease and compound screening.疾病与化合物筛选的网络视图。
Nat Rev Drug Discov. 2009 Apr;8(4):286-95. doi: 10.1038/nrd2826.
8
Drug target identification using side-effect similarity.利用副作用相似性进行药物靶点识别。
Science. 2008 Jul 11;321(5886):263-6. doi: 10.1126/science.1158140.
9
Human disease classification in the postgenomic era: a complex systems approach to human pathobiology.后基因组时代的人类疾病分类：人类病理生物学的复杂系统方法
Mol Syst Biol. 2007;3:124. doi: 10.1038/msb4100163. Epub 2007 Jul 10.
10
Homocysteine trials--clear outcomes for complex reasons.同型半胱氨酸试验——结果复杂，尚无明确结论。
N Engl J Med. 2006 Apr 13;354(15):1629-32. doi: 10.1056/NEJMe068060. Epub 2006 Mar 12.