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骨折至入院时间延迟:髋部骨折死亡率的新危险因素?

Delay from fracture to hospital admission: a new risk factor for hip fracture mortality?

机构信息

Internal Medicine Department, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.

出版信息

Osteoporos Int. 2012 Dec;23(12):2847-53. doi: 10.1007/s00198-012-1917-x.

DOI:10.1007/s00198-012-1917-x
PMID:22297734
Abstract

UNLABELLED

The relationship between surgical timing and hip fracture mortality is unknown in the context of developing countries where large delays to surgery are common. We observed that delay from fracture to hospital admission is associated with decreased survival after a hip fracture.

INTRODUCTION

To examine the relationship between the time interval from fracture to surgery as well as its subcomponents (time from fracture to hospital admission and time from admission to surgery) and hip fracture survival.

METHODS

The medical records of all patients aged 60 years and older admitted to a public university hospital in the city of Rio de Janeiro with a primary diagnosis of hip fracture between 1995 and 2000 were reviewed. Survival to hospital discharge and at 1 year were examined.

RESULTS

Among 343 patients included in the study, there were 18 (5.3%) in-hospital deaths, and 297 (86.6%) patients remained alive 1 year after surgery. Very long delays from the time of fracture to hospital admission (mean 3 days) and from hospital admission to surgery (mean 13 days) were identified. Increased time from fracture to hospital admission was associated with reduced survival to hospital discharge (hazard ratio [HR] 1.09, 95% CI 1.03-1.15, p  =  0.005) and reduced survival at 1 year after surgery (HR 1.07, 95% CI 1.03-1.10, p < 0.001). The interval of time from hospital admission to surgery was not associated with reduced survival to hospital discharge (HR 1.03, 95% CI 0.96-1.10, p = 0.379) or at 1 year after surgery (HR 1.03, 95% CI 0.99-1.07, p= 0.185).

CONCLUSIONS

If the association estimated in our study is causal, our results provide evidence that some hip fracture-related deaths could be prevented by improved patient access to appropriate and timely hospital care in the context of a developing country.

摘要

目的

研究从骨折到手术的时间间隔及其亚组分(从骨折到入院和从入院到手术的时间)与髋部骨折生存之间的关系。

方法

回顾了 1995 年至 2000 年间在里约热内卢市一所公立大学医院因初次诊断为髋部骨折而入院的所有 60 岁及以上患者的病历。检查了住院和 1 年的生存率。

结果

在纳入研究的 343 名患者中,有 18 例(5.3%)院内死亡,297 例(86.6%)患者在手术后 1 年仍存活。从骨折到入院和从入院到手术的时间都非常长(平均 3 天和 13 天)。从骨折到入院的时间增加与住院出院生存率降低(危险比[HR]1.09,95%可信区间[CI]1.03-1.15,p=0.005)和手术后 1 年生存率降低相关(HR 1.07,95% CI 1.03-1.10,p<0.001)。从入院到手术的时间间隔与住院出院(HR 1.03,95% CI 0.96-1.10,p=0.379)或手术后 1 年的生存率(HR 1.03,95% CI 0.99-1.07,p=0.185)无关。

结论

如果我们研究中估计的关联是因果关系,那么我们的研究结果提供了证据,表明在发展中国家,通过改善患者获得适当和及时的医院护理的途径,可以预防一些与髋部骨折相关的死亡。

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本文引用的文献

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Causes and effects of surgical delay in patients with hip fracture: a cohort study.髋部骨折患者手术延迟的原因和后果:一项队列研究。
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Does timing of surgery matter in fragility hip fractures?手术时机对脆性髋部骨折重要吗?
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Early admission is better-the time to admission (TTA) is associated with one-year mortality in hip fracture.早期入院更好——髋部骨折的入院时间(TTA)与一年死亡率相关。
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Pre-Hospital Delays Represent Unnoticed Intervals That Affect Mortality Rates in Geriatric Hip Fractures: A Prospective Cohort Study.院前延误代表影响老年髋部骨折死亡率的未被关注的时间段:一项前瞻性队列研究。
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The role of neutrophil percentage to albumin ratio in predicting 1-year mortality in elderly patients with hip fracture and external validation.中性粒细胞百分比与白蛋白比值在外周型股骨颈骨折患者中预测 1 年死亡率的作用及其外部验证。
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[Accuracy of the probabilistic record linkage methodology to ascertain deaths in survival studies].[在生存研究中确定死亡情况的概率性记录链接方法的准确性]
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Osteoporos Int. 2006 Oct;17(10):1569-76. doi: 10.1007/s00198-006-0173-3. Epub 2006 Jul 27.