Internal Medicine Department, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.
Osteoporos Int. 2012 Dec;23(12):2847-53. doi: 10.1007/s00198-012-1917-x.
The relationship between surgical timing and hip fracture mortality is unknown in the context of developing countries where large delays to surgery are common. We observed that delay from fracture to hospital admission is associated with decreased survival after a hip fracture.
To examine the relationship between the time interval from fracture to surgery as well as its subcomponents (time from fracture to hospital admission and time from admission to surgery) and hip fracture survival.
The medical records of all patients aged 60 years and older admitted to a public university hospital in the city of Rio de Janeiro with a primary diagnosis of hip fracture between 1995 and 2000 were reviewed. Survival to hospital discharge and at 1 year were examined.
Among 343 patients included in the study, there were 18 (5.3%) in-hospital deaths, and 297 (86.6%) patients remained alive 1 year after surgery. Very long delays from the time of fracture to hospital admission (mean 3 days) and from hospital admission to surgery (mean 13 days) were identified. Increased time from fracture to hospital admission was associated with reduced survival to hospital discharge (hazard ratio [HR] 1.09, 95% CI 1.03-1.15, p = 0.005) and reduced survival at 1 year after surgery (HR 1.07, 95% CI 1.03-1.10, p < 0.001). The interval of time from hospital admission to surgery was not associated with reduced survival to hospital discharge (HR 1.03, 95% CI 0.96-1.10, p = 0.379) or at 1 year after surgery (HR 1.03, 95% CI 0.99-1.07, p= 0.185).
If the association estimated in our study is causal, our results provide evidence that some hip fracture-related deaths could be prevented by improved patient access to appropriate and timely hospital care in the context of a developing country.
研究从骨折到手术的时间间隔及其亚组分(从骨折到入院和从入院到手术的时间)与髋部骨折生存之间的关系。
回顾了 1995 年至 2000 年间在里约热内卢市一所公立大学医院因初次诊断为髋部骨折而入院的所有 60 岁及以上患者的病历。检查了住院和 1 年的生存率。
在纳入研究的 343 名患者中,有 18 例(5.3%)院内死亡,297 例(86.6%)患者在手术后 1 年仍存活。从骨折到入院和从入院到手术的时间都非常长(平均 3 天和 13 天)。从骨折到入院的时间增加与住院出院生存率降低(危险比[HR]1.09,95%可信区间[CI]1.03-1.15,p=0.005)和手术后 1 年生存率降低相关(HR 1.07,95% CI 1.03-1.10,p<0.001)。从入院到手术的时间间隔与住院出院(HR 1.03,95% CI 0.96-1.10,p=0.379)或手术后 1 年的生存率(HR 1.03,95% CI 0.99-1.07,p=0.185)无关。
如果我们研究中估计的关联是因果关系,那么我们的研究结果提供了证据,表明在发展中国家,通过改善患者获得适当和及时的医院护理的途径,可以预防一些与髋部骨折相关的死亡。