Hof H, Mikus G
Labor Limbach, Heidelberg.
Z Gerontol Geriatr. 2013 Jan;46(1):64-70. doi: 10.1007/s00391-011-0280-4.
Candida infections of the skin, mucous membranes as well as of internal organs may be more frequent and more serious in the elderly. There are several biological reasons for this, for example, alterations in the immune system. Whereas Candida albicans remains the major pathogen, there has been a relative increase of Candida glabrata infections. This species is associated with higher mortality. Furthermore, C. glabrata is in general less susceptible to fluconazole, so that this drug does not represent the agent of first choice for the treatment of yeast infections. The choice of the antimycotic agent must take into consideration their inherent side effects and interaction profiles; echinocandins play a particular role in the treatment of yeast infections in the elderly. These drugs have low toxicities, low potential for interactions with co-medications, as well as broad and good activities against yeasts.
念珠菌感染皮肤、黏膜以及内脏在老年人中可能更为频繁和严重。这有几个生物学原因，例如免疫系统的改变。白色念珠菌仍然是主要病原体，而光滑念珠菌感染有相对增加。该菌种与更高的死亡率相关。此外，光滑念珠菌一般对氟康唑不太敏感，因此该药物并非治疗酵母菌感染的首选药物。抗真菌药物的选择必须考虑其固有的副作用和相互作用情况；棘白菌素类药物在老年人酵母菌感染的治疗中发挥着特殊作用。这些药物毒性低、与其他药物相互作用的可能性小以及对酵母菌有广泛且良好的活性。
