British Columbia Cancer Research Centre, Vancouver V5Z 1L3, Canada.
Genome Res. 2012 Feb;22(2):188-95. doi: 10.1101/gr.124354.111.
The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The vast accrual and public availability of multi-omics databases with associated clinical annotation including tumor histology, patient response, and outcome are a rich resource that has the potential to lead to rapid translation of high-throughput omics to improved overall survival. We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research.
基因组学时代极大地促进了对癌症生物学的理解。与此同时，癌症基因组的巨大复杂性以及即使在组织学上相似的肿瘤之间在全基因组（或组学）水平上存在的明显异质性也已经显露出来。多组学数据库的大量积累和公开可用性，以及相关的临床注释，包括肿瘤组织学、患者反应和结果，是一个丰富的资源，有可能将高通量组学快速转化为提高整体生存率。在这个高通量组学的新时代，我们专注于基因组分析的多维方法的独特优势，并讨论癌症人群变化对转化组学研究的影响。
