在活体老鼠大脑中进行纳米显微镜观察。
Nanoscopy in a living mouse brain.
机构信息
Department of NanoBiophotonics, Max Planck Institute (MPI) for Biophysical Chemistry, Göttingen, Germany.
出版信息
Science. 2012 Feb 3;335(6068):551. doi: 10.1126/science.1215369.
PMID:22301313
Abstract
We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time.
摘要
我们在活体高等动物中展示了超分辨率光学显微镜。受激发射损耗（STED）荧光纳米显微镜揭示了小鼠大脑皮层中的神经元，分辨率达到 70 纳米以下。可以在相关尺度上长时间观察树突棘及其细微变化。
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